ArticleJournal of Zhejiang University. Science. B2014
Effects of hypoxic exercise training on microRNA expression and lipid metabolism in obese rat livers.
Article in Journal of Zhejiang University. Science. B, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Protective effect of exercise on metabolic dysfunction‑associated fatty liver disease: Potential epigenetic mechanisms (Review).International journal of molecular medicine · 2025Review
- Caffeic acid dimethyl ether alleviates alcohol-induced hepatic steatosis via microRNA-378b-mediated CaMKK2-AMPK pathway.Bioengineered · 2022Article
- CircEZH2 Regulates Milk Fat Metabolism through miR-378b Sponge Activity.Animals : an open access journal from MDPI · 2022Article
- Impact of Physical Activity and Exercise on the Epigenome in Skeletal Muscle and Effects on Systemic Metabolism.Biomedicines · 2022Review
- BAIBA Involves in Hypoxic Training Induced Browning of White Adipose Tissue in Obese Rats.Frontiers in physiology · 2022Article
- microRNA-378b regulates ethanol-induced hepatic steatosis by targeting CaMKK2 to mediate lipid metabolism.Bioengineered · 2021Article
- Plasma exosome-derived microRNAs expression profiling and bioinformatics analysis under cross-talk between increased low-density lipoprotein cholesterol level and ATP-sensitive potassium channels variant rs1799858.Journal of translational medicine · 2020Article
- Lipolysis by downregulating miR-92a activates the Wnt/β-catenin signaling pathway in hypoxic rats.Biomedical reports · 2020Article
- Physical exercise and liver "fitness": Role of mitochondrial function and epigenetics-related mechanisms in non-alcoholic fatty liver disease.Molecular metabolism · 2020Review
- Adiponectin, Leptin and Visfatin in Hypoxia and its Effect for Weight Loss in Obesity.Frontiers in endocrinology · 2018Article
- Comparative analysis of hepatic miRNA levels in male marathon mice reveals a link between obesity and endurance exercise capacities.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Article
- Roles of microRNA and signaling pathway in osteoarthritis pathogenesis.Journal of Zhejiang University. Science. B · 2016Review
- bmo-miR-0001 and bmo-miR-0015 down-regulate expression of Bombyx mori fibroin light chain gene in vitro.Journal of Zhejiang University. Science. B · 2016Article
- Epigenomics, gestational programming and risk of metabolic syndrome.International journal of obesity (2005) · 2015Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the effects of hypoxic exercise training on microRNA (miRNA) expression and the role of miRNA expression in regulating lipid metabolism, 20 dietary-induced obese SD rats were divided into a normoxic sedentary group (N, n=10) and a hypoxic exercise training group (H, n=10). After four weeks, measurements were taken of body weight, body length, fat mass, serum lipid concentration, miRNAs differentially expressed in rat liver, and gene and protein expression levels of peroxisome proliferator activated receptor α (PPARα), fatty acid synthetase (FAS), and carnitine palmitoyl transferase 1A (CPT1A) in rat liver. Body weight, Lee's index, fat mass, fat/weight ratio, and serum levels of total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) were all significantly lower in the H group than in the N group (P<0.01). Six miRNAs expressed significantly differently in the liver (P<0.05). Specifically, expression levels of miR-378b were significantly lower in the H group than in the N group (P<0.05). Compared with the normoxic sedentary group, hypoxic exercise training resulted in a lower ratio of FAS mRNA to CPT1A mRNA (P<0.05), as well as lower CPT1A protein levels (P<0.01), while a higher ratio of FAS to CPT1A protein levels (P<0.01) was observed. In conclusion, hypoxic training may elevate the resistance of high fat diet induced obesity in rats by reducing the expression of miR-378b, and decrease the fatty acid mitochondrial oxidation in obese rat livers by decreasing the protein expression of CPT1A and increasing the protein expression ratio of FAS/CPT1A.
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Registered trials
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