ArticleeLife2014
Nuclear envelope protein MAN1 regulates clock through BMAL1.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- c-MYC is Transcribed in a Circadian Manner and Acts a Clock Disruptor whose Timing Minimizes its Impacts.bioRxiv : the preprint server for biology · 2026Article
- Nuclear envelope proteins in cancer: revisiting the significance of LEM-domain proteins.Frontiers in cell and developmental biology · 2026Review
- Choreography of lamina-associated domains: structure meets dynamics.FEBS letters · 2023Review
- Phosphorylation Promotes the Accumulation of PERIOD Protein Foci.Research (Washington, D.C.) · 2023Article
- Circadian Organelles: Rhythms at All Scales.Cells · 2021Review
- The Diverse Cellular Functions of Inner Nuclear Membrane Proteins.Cold Spring Harbor perspectives in biology · 2021Review
- Clock proteins regulate spatiotemporal organization of clock genes to control circadian rhythms.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Disrupted-in-schizophrenia 1 enhances the quality of circadian rhythm by stabilizing BMAL1.Translational psychiatry · 2021Article
- Introduction to the Clock System.Advances in experimental medicine and biology · 2021Article
- Nuclear Envelope Protein MAN1 Regulates the Drosophila Circadian Clock via Period.Neuroscience bulletin · 2019Article
- Circadian rhythms in the three-dimensional genome: implications of chromatin interactions for cyclic transcription.Clinical epigenetics · 2019Review
- Article
- Nuclear Lamin B1 Interactions With Chromatin During the Circadian Cycle Are Uncoupled From Periodic Gene Expression.Frontiers in genetics · 2019Article
- Structural basis for receptor-regulated SMAD recognition by MAN1.Nucleic acids research · 2018Article
- Genetic and epigenomic mechanisms of mammalian circadian transcription.Nature structural & molecular biology · 2016Review
- The circadian coordination of cell biology.The Journal of cell biology · 2016Review
- Circadian clocks and breast cancer.Breast cancer research : BCR · 2016Review
- SINC, a type III secreted protein of Chlamydia psittaci, targets the inner nuclear membrane of infected cells and uninfected neighbors.Molecular biology of the cell · 2015Article
- Chromatin Dynamics of Circadian Transcription.Current molecular biology reports · 2015Article
- Nuclear envelope regulates the circadian clock.Nucleus (Austin, Tex.) · 2015Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Circadian clocks serve as internal pacemakers that influence many basic homeostatic processes; consequently, the expression and function of their components are tightly regulated by intricate networks of feedback loops that fine-tune circadian processes. Our knowledge of these components and pathways is far from exhaustive. In recent decades, the nuclear envelope has emerged as a global gene regulatory machine, although its role in circadian regulation has not been explored. We report that transcription of the core clock component BMAL1 is positively modulated by the inner nuclear membrane protein MAN1, which directly binds the BMAL1 promoter and enhances its transcription. Our results establish a novel connection between the nuclear periphery and circadian rhythmicity, therefore bridging two global regulatory systems that modulate all aspects of bodily functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.