Evidence map›Paper›PMID 25182844›Full record

ArticleJournal of exposure science & environmental epidemiology

Population intervention models to estimate ambient NO2 health effects in children with asthma.

Jonathan M Snowden, Kathleen M Mortimer, Mi-Suk Kang Dufour, Ira B Tager

Abstract read
In one paragraph

Article in Journal of exposure science & environmental epidemiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. [Apply the Miettinen Formula to Assess the Health Benefits of the PMSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Article
  3. Pesticide exposure and asthma morbidity in children residing in urban, multi-family housing.Journal of exposure science & environmental epidemiology · 2024
    Article
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jonathan M SnowdenDepartment of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, USA.
Kathleen M MortimerDivision of Epidemiology, School of Public Health, University of California, Berkeley, California, USA.
Mi-Suk Kang DufourDivision of Epidemiology, School of Public Health, University of California, Berkeley, California, USA.
Ira B TagerDivision of Epidemiology, School of Public Health, University of California, Berkeley, California, USA.

Funding

Fresno Asthmatic Children's Environment Study (FACES)R01HL081521 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI TAGER, IRA B · 2006 to 2010
$3.8M
NHLBI NIH HHS R01 HL081521
6 · The paper itself

Abstract

Health effects of ambient air pollution are most frequently expressed in individual studies as responses to a standardized unit of air pollution changes (e.g., an interquartile interval), which is thought to enable comparison of findings across studies. However, this approach does not necessarily convey health effects in terms of a real-world air pollution scenario. In the present study, we use population intervention modeling to estimate the effect of an air pollution intervention that makes explicit reference to the observed exposure data and is identifiable in those data. We calculate the association between ambient summertime nitrogen dioxide (NO2) and forced expiratory flow between 25% and 75% of forced vital capacity (FEF25-75) in a cohort of children with asthma in Fresno, California. We scale the effect size to reflect NO2 abatement on a majority of summer days. The effect estimates were small, imprecise, and consistently indicated improved pulmonary function with decreased NO2. The effects ranged from -0.8% of mean FEF25-75 (95% confidence interval (CI): -3.4, 1.7) to -3.3% (95% CI: -7.5, 0.9). We conclude by discussing the nature and feasibility of the exposure change analyzed here given the observed air pollution profile, and we propose additional applications of population intervention models in environmental epidemiology.

Indexed as

Air PollutantsAsthmaCaliforniaChildFemaleForced Expiratory Flow RatesHumansInhalation ExposureLongitudinal StudiesMaleModels, StatisticalNitrogen DioxideProspective StudiesVital CapacityAir PollutantsNitrogen Dioxide

Identifiers

PMID25182844
PMCPMC4565777

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.