ArticleBMC biology2014
Episodic rolling and transient attachments create diversity in sperm swimming behavior.
Article in BMC biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Per capita sperm metabolism is density dependent.The Journal of experimental biology · 2024Pooled it
- Sperm hyperactivation drives a circling-and-wandering swimming behavior.Nature communications · 2026Article
- Swimming by Spinning: Spinning-Top Type Rotations Regularize Sperm Swimming Into Persistently Progressive Paths in 3D.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Human sperm cooperate to transit highly viscous regions on the competitive pathway to fertilization.Communications biology · 2023Article
- In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes.Nature structural & molecular biology · 2023Article
- An assessment tool for computer-assisted semen analysis (CASA) algorithms.Scientific reports · 2022Article
- cAMP and the Fibrous Sheath Protein CABYR (CaInternational journal of molecular sciences · 2022Article
- CatSper and its CaM-like CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Rolling controls sperm navigation in response to the dynamic rheological properties of the environment.eLife · 2021Article
- Reconstruction of the three-dimensional beat pattern underlying swimming behaviors of sperm.The European physical journal. E, Soft matter · 2021Article
- A dynamic basal complex modulates mammalian sperm movement.Nature communications · 2021Article
- Micromotor-mediated sperm constrictions for improved swimming performance.The European physical journal. E, Soft matter · 2021Article
- The multi-scale architecture of mammalian sperm flagella and implications for ciliary motility.The EMBO journal · 2021Article
- RETRACTED: Human sperm uses asymmetric and anisotropic flagellar controls to regulate swimming symmetry and cell steering.Science advances · 2020Article
- Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane CaThe EMBO journal · 2020Article
- 3D imaging of sex-sorted bovine spermatozoon locomotion, head spin and flagellum beating.Scientific reports · 2018Article
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- Label-free 3D computational imaging of spermatozoon locomotion, head spin and flagellum beating over a large volume.Light, science & applications · 2018Article
- Four-dimensional analysis by high-speed holographic imaging reveals a chiral memory of sperm flagella.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrequency and asymmetry of the flagellar waveform of sperm are controlled by cAMP-mediated and Ca(2+)-dependent signaling pathways, but additional mechanisms modulate sperm swimming behavior. Here, high-speed imaging of free-swimming mouse sperm simultaneously reports flagellar waveform, orientation of sperm head, and swimming paths.
resultsWe found many sperm roll (rotate around their long axis) at intervals closely tied to flagellar beat frequency, allowing an asymmetrical flagellar beat to form linear averaged swimming trajectories. For non-rolling sperm, flagellar waveform asymmetry dictated circular path trajectories. Sparse rolling produced abrupt changes in swimming trajectories that occurred spontaneously, unaffected by blockade or engagement of cAMP- or Ca(2+)-mediated flagellar responses. Still other sperm loosely attached (tethered) to surfaces or other cells. Sperm tethered to each other in duos or trios could have narrowed swimming paths, allowing enhanced progression.
conclusionsWe propose that transient episodes of rolling and reversible attachments are organizing principles that determine diverse swimming behaviors, which may have roles in selection of the fertilizing sperm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.