Evidence map›Paper›PMID 25182491›Full record

ArticleJournal of bacteriology2014

Cross-species comparison of the Burkholderia pseudomallei, Burkholderia thailandensis, and Burkholderia mallei quorum-sensing regulons.

Charlotte D Majerczyk, Mitchell J Brittnacher, Michael A Jacobs, Christopher D Armour, Matthew C Radey, Richard Bunt, Hillary S Hayden, Ryland Bydalek, E Peter Greenberg

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of bacteriology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Frontiers in microbiology · 2024
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  7. Sequence-based detection and typing procedures forFrontiers in veterinary science · 2022
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  9. Genomic pattern analysis ofIranian journal of microbiology · 2021
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Quorum Sensing Controls Both Rhamnolipid and Polyhydroxyalkanoate Production inFrontiers in bioengineering and biotechnology · 2020
    Article
  18. Article
  19. Article
  20. An in situ high-throughput screen identifies inhibitors of intracellularProceedings of the National Academy of Sciences of the United States of America · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Charlotte D MajerczykDepartment of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA.
Mitchell J BrittnacherDepartment of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA.
Michael A JacobsDepartment of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA.
Christopher D ArmourNuGen, San Carlos, California, USA.
Matthew C RadeyDepartment of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA.
Richard BuntDepartment of Chemistry and Biochemistry, Middlebury College, Middlebury, Vermont, USA.
Hillary S HaydenDepartment of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA.
Ryland BydalekDepartment of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA.
E Peter GreenbergDepartment of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA epgreen@uw.edu.
University of Washington · USMiddlebury College · US

Funding

Variation in Human Innate ImmunityU54AI057141 · NIAID · UNIVERSITY OF WASHINGTON · PI WURFEL, MARTIN M. · 2003 to 2013
$102.3M
Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss, Lucas R Hoffman · 2010 to 2026
$21.4M
QUORUM SENSING IN PSEUDOMONAS AERUGINOSAR01GM059026 · NIGMS · UNIVERSITY OF WASHINGTON · PI GREENBERG, EVERETT P · 1999 to 2019
$6.5M
NIAID NIH HHS U54 AI057141NIAID NIH HHS U54AI057141NIDDK NIH HHS P30 DK089507NIGMS NIH HHS GM-59026NIGMS NIH HHS R01 GM059026
6 · The paper itself

Abstract

Burkholderia pseudomallei, Burkholderia thailandensis, and Burkholderia mallei (the Bptm group) are close relatives with very different lifestyles: B. pseudomallei is an opportunistic pathogen, B. thailandensis is a nonpathogenic saprophyte, and B. mallei is a host-restricted pathogen. The acyl-homoserine lactone quorum-sensing (QS) systems of these three species show a high level of conservation. We used transcriptome sequencing (RNA-seq) to define the quorum-sensing regulon in each species, and we performed a cross-species analysis of the QS-controlled orthologs. Our analysis revealed a core set of QS-regulated genes in all three species, as well as QS-controlled factors shared by only two species or unique to a given species. This global survey of the QS regulons of B. pseudomallei, B. thailandensis, and B. mallei serves as a platform for predicting which QS-controlled processes might be important in different bacterial niches and contribute to the pathogenesis of B. pseudomallei and B. mallei.

Indexed as

Bacterial ProteinsBurkholderiaBurkholderia malleiBurkholderia pseudomalleiGene Expression Regulation, BacterialQuorum SensingRegulonSpecies SpecificityBacterial Proteins

Identifiers

PMID25182491
PMCPMC4248825
OpenAlexW2083713390

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.