ArticleEnvironmental science and pollution research international2015
Exposure to perfluorinated compounds: in vitro study on thyroid cells.
Article in Environmental science and pollution research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 60 citations in OpenAlex.
- Serum per- and polyfluoroalkyl substances in relation to circulating thyroxine levels and thyroid cancer risk: results from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial cohort.Environment international · 2026Article
- Sustainable remediation strategies for emerging PFAS contaminants in water.RSC advances · 2025Review
- The association between per-fluoroalkyl and poly-fluoroalkyl substances exposure and thyroid cancer: a meta-analysis.Journal of environmental health science & engineering · 2025Article
- Review
- Associations of per- and polyfluoroalkyl substances with maternal early second trimester sex-steroid hormones.International journal of hygiene and environmental health · 2024Article
- Association between per- and polyfluoroalkyl substances exposure and thyroid function biomarkers among females attending a fertility clinic.Environmental pollution (Barking, Essex : 1987) · 2024Article
- Perfluorooctanesulfonic acid (PFOS) disrupts cadherin-16 in the developing rat thyroid gland.Current research in toxicology · 2024Article
- Perfluorooctanoic acid-induced cell death via the dual roles of ROS-MAPK/ERK signaling in ameloblast-lineage cells.Ecotoxicology and environmental safety · 2023Article
- A New Method for Environmental Risk Assessment of Pollutants Based on Multi-Dimensional Risk Factors.Toxics · 2022Article
- Endocrine-Disrupting Chemicals and Breast Cancer: Disparities in Exposure and Importance of Research Inclusivity.Endocrinology · 2022Review
- Review
- Comparative Evaluation of the Effects of Legacy and New Generation Perfluoralkyl Substances (PFAS) on Thyroid CellsFrontiers in endocrinology · 2022Article
- The new generation PFAS C6O4 does not produce adverse effects on thyroid cells in vitro.Journal of endocrinological investigation · 2021Article
- Review
- Thyroid Disrupting Effects of Old and New Generation PFAS.Frontiers in endocrinology · 2020Review
- Effect of long- and short-chain perfluorinated compounds on cultured thyroid cells viability and response to TSH.Journal of endocrinological investigation · 2019Article
- Genetic background and window of exposure contribute to thyroid dysfunction promoted by low-dose exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice.Scientific reports · 2018Article
- Thyroid disruption by perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA).Journal of endocrinological investigation · 2017Review
- Cosmetics as endocrine disruptors: are they a health risk?Reviews in endocrine & metabolic disorders · 2015Review
- Thyroid nodules and thyroid autoimmunity in the context of environmental pollution.Reviews in endocrine & metabolic disorders · 2015Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are widely used perfluorinated chemicals (PFCs). Previous studies detected PFOA and PFOS in human tissues including the thyroid gland. There are no studies on the in vitro effects of PFOA and PFOS on thyroid cells. Our study was aimed at evaluating the effect of the in vitro exposure to PFOA and PFOS on thyroid cell proliferation and viability. These objectives were investigated using Fisher rat thyroid line-5 (FRTL-5) cells. FRTL-5 cells cultured in the presence of PFOA and PFOS at concentrations up to 10(4) nM do not display changes in their viability and proliferation rate, while at a concentration of 10(5) nM of either PFCs, a significant inhibition of cell proliferation, mainly due to increased cell death, was found. PFOA and PFOS were detected in FRTL-5 cell pellets after 72 h of incubation with PFCs but not in control cultures. When FRTL-5 were incubated with PFCs then washed in PBS and re-cultured for 72 h without PFCs in the medium, no detectable concentrations of PFOA and PFOS were measured in the cell pellet. This indicates that PFOA and PFOS enter thyroid cells by a gradient-based passive diffusion mechanism. Future studies are required to evaluate the potential toxic effect resulting from prolonged in vivo exposure to even lower concentrations of PFCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.