ArticleEuropean journal of human genetics : EJHG2015
Fine-scale human genetic structure in Western France.
Article in European journal of human genetics : EJHG, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Trial
- Whole-Genome Sequencing in Galicia Reveals Male-Biased Pre-Islamic North African Ancestry, Subtle Population Structure, and Microgeographic Patterns of Disease Risk.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Human genetic structure in Northwest France provides new insights into West European historical demography.Nature communications · 2024Article
- Revealing the recent demographic history of Europe via haplotype sharing in the UK Biobank.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Challenging the utility of polygenic scores for social science: Environmental confounding, downward causation, and unknown biology.The Behavioral and brain sciences · 2022Article
- The genetic structure of Norway.European journal of human genetics : EJHG · 2021Article
- Review
- Fine scale human genetic structure in three regions of Cameroon reveals episodic diversifying selection.Scientific reports · 2021Article
- Article
- The place of metropolitan France in the European genomic landscape.Human genetics · 2020Article
- The genetic history of France.European journal of human genetics : EJHG · 2020Article
- Population and evolutionary genetics of the PAH locus to uncover overdominance and adaptive mechanisms in phenylketonuria: Results from a multiethnic study.EBioMedicine · 2020Article
- Rare Coding Variants in ANGPTL6 Are Associated with Familial Forms of Intracranial Aneurysm.American journal of human genetics · 2018Article
- Article
- The impact of a fine-scale population stratification on rare variant association test results.PloS one · 2018Article
- The Irish DNA Atlas: Revealing Fine-Scale Population Structure and History within Ireland.Scientific reports · 2017Article
- Fine-Scale Genetic Structure in Finland.G3 (Bethesda, Md.) · 2017Article
- Recent advances in the study of fine-scale population structure in humans.Current opinion in genetics & development · 2016Review
- Article
- Isolation-by-distance-and-time in a stepping-stone model.Theoretical population biology · 2016Article
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Authors and funding
22 authors.
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Abstract
The difficulties arising from association analysis with rare variants underline the importance of suitable reference population cohorts, which integrate detailed spatial information. We analyzed a sample of 1684 individuals from Western France, who were genotyped at genome-wide level, from two cohorts D.E.S.I.R and CavsGen. We found that fine-scale population structure occurs at the scale of Western France, with distinct admixture proportions for individuals originating from the Brittany Region and the Vendée Department. Genetic differentiation increases with distance at a high rate in these two parts of Northwestern France and linkage disequilibrium is higher in Brittany suggesting a lower effective population size. When looking for genomic regions informative about Breton origin, we found two prominent associated regions that include the lactase region and the HLA complex. For both the lactase and the HLA regions, there is a low differentiation between Bretons and Irish, and this is also found at the genome-wide level. At a more refined scale, and within the Pays de la Loire Region, we also found evidence of fine-scale population structure, although principal component analysis showed that individuals from different departments cannot be confidently discriminated. Because of the evidence for fine-scale genetic structure in Western France, we anticipate that rare and geographically localized variants will be identified in future full-sequence analyses.
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