ArticlePloS one2014
The activity-integrated method for quality assessment of reduning injection by on-line DPPH-CE-DAD.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Recent Applications of Capillary Electrophoresis in the Determination of Active Compounds in Medicinal Plants and Pharmaceutical Formulations.Molecules (Basel, Switzerland) · 2021Review
- Antioxidant Effects and Cytoprotective Potentials of Herbal Tea against HBioMed research international · 2020Article
- Microwave-Assisted Extraction Combined with In-Capillary [Fe(ferrozine)Molecules (Basel, Switzerland) · 2019Article
- A powerful on line ABTSScientific reports · 2018Article
- A Green Antioxidant Activity-Integrated Dual-Standard Method for Rapid Evaluation of the Quality of Traditional Chinese Medicine Xuebijing Injection by On-Line DPPH-CE-DAD.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Chinese herbal medicines as a source of molecules with anti-enterovirus 71 activity.Chinese medicine · 2016Article
- Multiscale Modeling of Drug-induced Effects of ReDuNing Injection on Human Disease: From Drug Molecules to Clinical Symptoms of Disease.Scientific reports · 2015Article
- On-line quantitative monitoring of liquid-liquid extraction of Lonicera japonica and Artemisia annua using near-infrared spectroscopy and chemometrics.Pharmacognosy magazineArticle
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Authors and funding
11 authors.
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Abstract
A sensitive on-line DPPH-CE-DAD method was developed and validated for both screening and determining the concentration of seven antioxidants of Reduning injection. The pH and concentrations of buffer solution, SDS, β-CD and organic modifier were studied for the detection of DPPH and seven antioxidants. By on-line mixing DPPH and sample solution, a DPPH-CE method for testing the antioxidant activity of the complex matrix was successfully established and used to screen the antioxidant components of Reduning injection. Then, antioxidant components including caffeic acid, isochlorogenic acid A, isochlorogenic acid B, isochlorogenic acid C, chlorogenic acid, neochlorogenic acid and cryptochlorogenic acid were quantified by the newly established CE-DAD method. Finally, the total antioxidant activity and the multiple active components were selected as markers to evaluate the quality of Reduning injection. The results demonstrated that the on-line DPPH-CE-DAD method was reagent-saving, rapid and feasible for on-line simultaneous determination of total pharmacological activity and contents of multi-components samples. It was also a powerful method for evaluating the quality control and mechanism of action of TCM injection.
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