ArticleNeurosurgery2014
Roles of estrogen in the formation of intracranial aneurysms in ovariectomized female mice.
Article in Neurosurgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 64 citations in OpenAlex.
- Roles of Sirtuin-1 in the Prevention of Intracranial Aneurysm Rupture in Mice.Hypertension (Dallas, Tex. : 1979) · 2026Article
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- Longitudinal MR angiographic evaluation of circle of Willis morphologic remodeling and induced aneurysms in Hashimoto rat cerebral aneurysm model.Scientific reports · 2026Article
- Animal Models of Intracranial Aneurysms: History, Advances, and Future Perspectives.Translational stroke research · 2025Review
- Plasma Estrogen Levels and Aneurysmal Subarachnoid Hemorrhage in Women.World neurosurgery · 2024Article
- Development of an Injectable, ECM-Derivative Embolic for the Treatment of Cerebral Saccular Aneurysms.Biomacromolecules · 2024Article
- Vitamin D deficiency promotes intracranial aneurysm rupture.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Sex differences in patients with and without high-risk factors associated with aneurysmal subarachnoid hemorrhage.Acta neurochirurgica · 2024Article
- Pharmacological Inhibition of Epidermal Growth Factor Receptor Prevents Intracranial Aneurysm Rupture by Reducing Endoplasmic Reticulum Stress.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Current Mouse Models of Intracranial Aneurysms: Analysis of Pharmacological Agents Used to Induce Aneurysms and Their Impact on Translational Research.Journal of the American Heart Association · 2024Review
- Dietary Iron Restriction Protects against Aneurysm Rupture in a Mouse Model of Intracranial Aneurysm.Cerebrovascular diseases (Basel, Switzerland) · 2024Article
- Neutrophils: Novel Contributors to Estrogen-Dependent Intracranial Aneurysm Rupture Via Neutrophil Extracellular Traps.Journal of the American Heart Association · 2023Article
- Sex-related differences in symptom presentation of patients with aneurysmal subarachnoid hemorrhage.F1000Research · 2022Article
- Intracranial Aneurysms Induced byFrontiers in neurology · 2022Article
- Why Are Women Predisposed to Intracranial Aneurysm?Frontiers in cardiovascular medicine · 2022Review
- RNA Sequencing Data from Human Intracranial Aneurysm Tissue Reveals a Complex Inflammatory Environment Associated with Rupture.Molecular diagnosis & therapy · 2021Article
- Endogenous animal models of intracranial aneurysm development: a review.Neurosurgical review · 2021Review
- Article
- Neutrophil Extracellular Traps Promote the Development of Intracranial Aneurysm Rupture.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEpidemiological studies have indicated that postmenopausal women have a higher incidence of intracranial aneurysms than men in the same age group.
objectiveTo investigate whether estrogen or estrogen receptors (ERs) mediate protective effects against the formation of intracranial aneurysms.
methodsIntracranial aneurysms were induced in mice by combining a single injection of elastase into the cerebrospinal fluid with deoxycorticosterone acetate salt hypertension. The mice were treated with estrogen (17β-estradiol), an ERα agonist (propyl pyrazole triol), and an ERβ agonist (diarylpropionitrile) with and without a nitric oxide synthase inhibitor.
resultsThe ovariectomized female mice had a significantly higher incidence of aneurysms than the male mice, which was consistent with findings in previous epidemiological studies. In ovariectomized female mice, an ERβ agonist, but not an ERα agonist or 17β-estradiol, significantly reduced the incidence of aneurysms. The protective effect of the ERβ agonist was absent in the ovariectomized ERβ knockout mice. The protective effect of the ERβ agonist was negated by treatment with a nitric oxide synthase inhibitor.
conclusionThe effects of sex, menopause, and estrogen treatment observed in this animal study were consistent with previous epidemiological findings. Stimulation of estrogen receptor-β was protective against the formation of intracranial aneurysms in ovariectomized female mice.
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