SynthesisThe Journal of clinical endocrinology and metabolism2014
A meta-analysis comparing the biochemistry of primary hyperparathyroidism in youths to the biochemistry of primary hyperparathyroidism in adults.
Synthesis in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Primary hyperparathyroidism incidence in northeastern Italy: A large population-based study.Journal of endocrinological investigation · 2026Article
- Parathyroidectomy in the Treatment of Childhood Hyperparathyroidism: A Single-Institution Experience.Children (Basel, Switzerland) · 2025Article
- Long-Term Consequences of Misdiagnosis of Parathyroid Adenomas in Pediatric Patients.Case reports in pediatrics · 2025Article
- Atypical parathyroid adenoma with severe bone manifestations in early adolescence.BMJ case reports · 2024Article
- Pitfalls in the Diagnosis of Primary Hyperparathyroidism in a Sudanese Adolescent Boy; a case disguised as rickets.BMC endocrine disorders · 2022Article
- Primary Hyperparathyroidism From Ectopic Parathyroid Adenoma in a 12-Year-Old With Slipped Capital Femoral Epiphysis.Journal of the Endocrine Society · 2022Article
- Primary hyperparathyroidism in pregnancy: observations from the Indian PHPT registry.Journal of endocrinological investigation · 2021Observational
- "Primary Hyperparathyroidism (PHPT) in Children: Two Case Reports and Review of the Literature".Case reports in endocrinology · 2021Article
- Parathyroid carcinoma in a 13-year-old girl with a long-term survival.Surgical case reports · 2020Article
- Single Gland, Ectopic Location: Adenomas are Common Causes of Primary Hyperparathyroidism in Children and Adolescents.World journal of surgery · 2020Article
- Bilateral Genu Valgum in an Adolescent with Primary Hyperparathyroidism: A Case Report and Review of Literature.Journal of the ASEAN Federation of Endocrine Societies · 2020Article
- Serum Calcium to Phosphorous (Ca/P) Ratio Is a Simple, Inexpensive, and Accurate Tool in the Diagnosis of Primary Hyperparathyroidism.JBMR plus · 2018Article
- Article
- Outcomes of minimally invasive parathyroidectomy in pediatric patients with primary hyperparathyroidism owing to parathyroid adenoma: A single institution experience.Journal of pediatric surgery · 2017Article
- PHPT Masquerading as Rickets in Children and Presenting with Rare Skeletal Manifestations: Report of Three Cases and Review of Literature.Indian journal of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
contextThe distinctive presentation of primary hyperparathyroidism (PHPT) in adults and youths suggest that PHPT is a fundamentally different disease in these two groups.
objectiveTo understand the difference in PHPT between adults and youths we compared the biochemistry of PHPT in these two groups.
designThis study is a systematic review and meta-analysis of retrospective studies published 1966-2014 on PHPT. DATA SOURCES: All studies were obtained through Medline (1966-2014). STUDY SELECTION AND DATA EXTRACTION: Only studies that included post-surgical subjects and that explicitly described biochemical results from more than one decade were included. Data were extracted from each article to generate the mean and SE for multiple biochemical parameters. DATA SYNTHESIS: We analyzed 16 studies describing 268 unique youths and 2405 adults with PHPT. Youths with PHPT had significantly (P < .05) greater serum and urinary calcium than adults with PHPT (3.2 ± 0.1 mmol/L vs 2.8 ± 0.0 mmol/L for serum calcium, and 9.95 ± 1.26 mmol/d vs 7.15 ± 0.56 mmol/d for urine calcium, [mean ± SEM]). There were no significant differences in serum intact PTH, phosphorus, or alkaline phosphatase.
conclusionsJuvenile PHPT has greater hypercalcemia and hypercalciuria than adult PHPT at similar concentrations of serum intact PTH. These observations suggest that there are differences in the pathophysiology of PHPT between juvenile and adult patients who reflect an apparent decrease in the sensitivity of the parathyroid adenoma to negative feedback by calcium and increased sensitivity of target tissues to the effects of PTH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.