ArticleThe Journal of clinical endocrinology and metabolism2014
Ovarian cancer-related hypophosphatemic osteomalacia--a case report.
Article in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- A Rare Association Between Osteomalacia, Phosphaturic Mesenchymal Tumor, and Ovarian Cancer: A Case Report and Literature Review.Calcified tissue international · 2024Review
- Tumor-induced Osteomalacia: A Case Report and Etiological Analysis with Literature Review.Orthopaedic surgery · 2023Review
- Unusual phosphaturic mesenchymal tumor mimicking osteoid osteoma.Radiology case reports · 2023Article
- Ovarian Teratoma Causing Oncogenic Osteomalacia: An Instance of Serendipity.Journal of obstetrics and gynaecology of India · 2022Article
- Paraneoplastic Secretion of Multiple Phosphatonins From a Deep Fibrous Histiocytoma Causing Oncogenic Osteomalacia.The Journal of clinical endocrinology and metabolism · 2021Article
- Tumor-Induced Osteomalacia.Calcified tissue international · 2021Review
- Role of Fibroblast Growth Factor 23 (FGF23) and αKlotho in Cancer.Frontiers in cell and developmental biology · 2020Review
- Ectopic expression of Klotho in fibroblast growth factor 23 (FGF23)-producing tumors that cause tumor-induced rickets/osteomalacia (TIO).Bone reports · 2019Article
- Tumor-induced osteomalacia.Osteoporosis and sarcopenia · 2018Review
- Phosphaturic mesenchymal tumors: what an endocrinologist should know.Journal of endocrinological investigation · 2018Review
- The Foot That Broke Both Hips: A Case Report and Literature Review of Tumor-Induced Osteomalacia.Case reports in rheumatology · 2017Article
- Tumor-induced Osteomalacia Caused by a Parotid Tumor.Internal medicine (Tokyo, Japan) · 2017Article
- Tumor induced osteomalacia secondary to anaplastic thyroid carcinoma: A case report and review of the literature.Bone reports · 2016Article
- Tumor-induced osteomalacia due to a recurrent mesenchymal tumor overexpressing several growth factor receptors.Endocrinology, diabetes & metabolism case reports · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextTumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused primarily by benign mesenchymal tumors. It has been associated with malignancies in rare cases. High serum levels of fibroblast growth factor (FGF) 23 reported in a group of patients with ovarian cancer had normal serum phosphate levels. There had been no ovarian cancer-related hypophosphatemic osteomalacia in a search of the literature.
objectiveWe investigated a 57-year-old woman with progressive low back pain. DESIGN AND
interventionClinical, biochemical, and radiological assessments were performed. The patient's serum phosphate and FGF23 levels were evaluated at baseline and after treatment for ovarian cancer.
resultsThe patient presented with progressive low back pain and weight loss during the previous 6 months. Imaging studies revealed low bone mineral density and multiple suspicious spinal metastatic lesions. Laboratory examination showed hypophosphatemia, hyperphosphaturia, normocalcemia, an elevated serum alkaline phosphatase level, and an elevated serum FGF23 level. Because TIO was suspected, a tumor survey was performed, and ovarian carcinoma with multiple metastasis was detected. After surgery and chemotherapy treatments for ovarian cancer, the serum phosphate and FGF23 levels returned to normal, and the low back pain improved.
conclusionsTo our knowledge, this is the first case of ovarian cancer-related hypophosphatemic osteomalacia reported in the literature. TIO should be considered in patients with ovarian cancer presenting with weakness, bone pain, and fractures. Investigation of TIO is appropriate when these patients present hypophosphatemia.
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