ArticlePloS one2014
Directional collective cell migration emerges as a property of cell interactions.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Protrusion force and cell-cell adhesion-induced polarity alignment govern collective migration modes.Biophysical journal · 2025Article
- Internal cohesion gradient as a novel mechanism of collective cell migration.PLoS computational biology · 2025Article
- Polarity and migration of cranial and cardiac neural crest cells: underlying molecular mechanisms and disease implications.Frontiers in cell and developmental biology · 2024Review
- Article
- Directional Persistence of Cell Migration in Schizophrenia Patient-Derived Olfactory Cells.International journal of molecular sciences · 2021Article
- Filopodia-based contact stimulation of cell migration drives tissue morphogenesis.Nature communications · 2021Article
- Bridging from single to collective cell migration: A review of models and links to experiments.PLoS computational biology · 2020Review
- Rules of collective migration: from the wildebeest to the neural crest.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Modelling collective cell migration: neural crest as a model paradigm.Journal of mathematical biology · 2020Article
- Modelling chase-and-run migration in heterogeneous populations.Journal of mathematical biology · 2020Article
- Sustained Oscillations of Epithelial Cell Sheets.Biophysical journal · 2019Article
- Adapting a Plant Tissue Model to Animal Development: Introducing Cell Sliding into VirtualLeaf.Bulletin of mathematical biology · 2019Article
- Neural crest streaming as an emergent property of tissue interactions during morphogenesis.PLoS computational biology · 2019Article
- Cellular organization and boundary formation in craniofacial development.Genesis (New York, N.Y. : 2000) · 2019Review
- Non-local Parabolic and Hyperbolic Models for Cell Polarisation in Heterogeneous Cancer Cell Populations.Bulletin of mathematical biology · 2018Article
- Dancing Styles of Collective Cell Migration: Image-Based Computational Analysis of JRAB/MICAL-L2.Frontiers in cell and developmental biology · 2018Review
- Neural crest and cancer: Divergent travelers on similar paths.Mechanisms of development · 2017Review
- Connecting individual to collective cell migration.Scientific reports · 2017Article
- Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts.Nature communications · 2017Article
- Physical models of collective cell motility: from cell to tissue.Journal of physics D: Applied physics · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Collective cell migration is a fundamental process, occurring during embryogenesis and cancer metastasis. Neural crest cells exhibit such coordinated migration, where aberrant motion can lead to fatality or dysfunction of the embryo. Migration involves at least two complementary mechanisms: contact inhibition of locomotion (a repulsive interaction corresponding to a directional change of migration upon contact with a reciprocating cell), and co-attraction (a mutual chemoattraction mechanism). Here, we develop and employ a parameterized discrete element model of neural crest cells, to investigate how these mechanisms contribute to long-range directional migration during development. Motion is characterized using a coherence parameter and the time taken to reach, collectively, a target location. The simulated cell group is shown to switch from a diffusive to a persistent state as the response-rate to co-attraction is increased. Furthermore, the model predicts that when co-attraction is inhibited, neural crest cells can migrate into restrictive regions. Indeed, inhibition of co-attraction in vivo and in vitro leads to cell invasion into restrictive areas, confirming the prediction of the model. This suggests that the interplay between the complementary mechanisms may contribute to guidance of the neural crest. We conclude that directional migration is a system property and does not require action of external chemoattractants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.