ArticleZebrafish2014
The involvement of cholesterol in sepsis and tolerance to lipopolysaccharide highlighted by the transcriptome analysis of zebrafish (Danio rerio).
Article in Zebrafish, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Transcriptomic study of lipopolysaccharide-induced sepsis damage in a mouse heart model.Experimental and therapeutic medicine · 2020Article
- Modeling Inflammation in Zebrafish for the Development of Anti-inflammatory Drugs.Frontiers in cell and developmental biology · 2020Review
- Early Life Glucocorticoid Exposure Modulates Immune Function in Zebrafish (Frontiers in immunology · 2020Article
- Comparative Study of Immune Reaction Against Bacterial Infection From Transcriptome Analysis.Frontiers in immunology · 2019Review
- Modeling hypercholesterolemia and vascular lipid accumulation in LDL receptor mutant zebrafish.Journal of lipid research · 2018Article
- CNBP acts as a key transcriptional regulator of sustained expression of interleukin-6.Nucleic acids research · 2017Article
- Conserved gene regulation during acute inflammation between zebrafish and mammals.Scientific reports · 2017Article
- Effects of Ringer's sodium pyruvate solution on serum tumor necrosis factor-α and interleukin-6 upon septic shock.Pakistan journal of medical sciences · 2015Article
- Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Septic shock is the most common cause of death in intensive care units due to an aggressive inflammatory response that leads to multiple organ failure. However, a lipopolysaccharide (LPS) tolerance phenomenon (a nonreaction to LPS), is also often described. Neither the inflammatory response nor the tolerance is completely understood. In this work, both of these responses were analyzed using microarrays in zebrafish. Fish that were 4 or 6 days postfertilization (dpf) and received a lethal dose (LD) of LPS exhibited 100% mortality in a few days. Their transcriptome profile, even at 4 dpf, resembled the profile in humans with severe sepsis. Moreover, we selected 4-dpf fish to set up a tolerance protocol: fish treated with a nonlethal concentration of Escherichia coli LPS exhibited complete protection against the LD of LPS. Most of the main inflammatory molecules described in mammals were represented in the zebrafish microarray experiments. Additionally and focusing on this tolerance response, the use of cyclodextrins may mobilize cholesterol reservoirs to decrease mortality after a LD dose of LPS. Therefore, it is possible that the use of the whole animal could provide some clues to enhance the understanding of the inflammatory/tolerance response and to guide drug discovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.