ArticleJournal of the American Chemical Society2014
Discovery and characterization of a disulfide-locked C(2)-symmetric defensin peptide.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Mammals' humoral immune proteins and peptides targeting the bacterial envelope: from natural protection to therapeutic applications against multidrug-resistant Gram-negatives.Biological reviews of the Cambridge Philosophical Society · 2022Review
- Efficient preparation of unsymmetrical disulfides by nickel-catalyzed reductive coupling strategy.Nature communications · 2022Article
- Polysulfurating reagent design for unsymmetrical polysulfide construction.Nature communications · 2018Article
- Artificial disulfide-rich peptide scaffolds with precisely defined disulfide patterns and a minimized number of isomers.Chemical science · 2017Article
- Rattusin structure reveals a novel defensin scaffold formed by intermolecular disulfide exchanges.Scientific reports · 2017Article
- Defensins, lectins, mucins, and secretory immunoglobulin A: microbe-binding biomolecules that contribute to mucosal immunity in the human gut.Critical reviews in biochemistry and molecular biology · 2017Review
- Sperm-Coating Beta-Defensin 126 Is a Dissociation-Resistant Dimer Produced by Epididymal Epithelium in the Bovine Reproductive Tract.Biology of reproduction · 2016Article
- An Internal Disulfide Locks a Misfolded Aggregation-prone Intermediate in Cataract-linked Mutants of Human γD-Crystallin.The Journal of biological chemistry · 2016Article
- Conformational landscape and pathway of disulfide bond reduction of human alpha defensin.Protein science : a publication of the Protein Society · 2015Article
- Antimicrobial peptides in 2014.Pharmaceuticals (Basel, Switzerland) · 2015Review
- Visualizing attack of Escherichia coli by the antimicrobial peptide human defensin 5.Biochemistry · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We report the discovery of HD5-CD, an unprecedented C2-symmetric β-barrel-like covalent dimer of the cysteine-rich host-defense peptide human defensin 5 (HD5). Dimerization results from intermonomer disulfide exchange between the canonical α-defensin Cys(II)-Cys(IV) (Cys(5)-Cys(20)) bonds located at the hydrophobic interface. This disulfide-locked dimeric assembly provides a new element of structural diversity for cysteine-rich peptides as well as increased protease resistance, broad-spectrum antimicrobial activity, and enhanced potency against the opportunistic human pathogen Acinetobacter baumannii.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.