Trial reportChest2014
Impact of early mobilization on glycemic control and ICU-acquired weakness in critically ill patients who are mechanically ventilated.
Trial report in Chest, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 160 citations in OpenAlex.
- Rehabilitation in the Intensive Care Unit for Adults with Traumatic Brain Injury: A Systematic Review and Meta-analysis.Neurocritical care · 2026Pooled it
- Corticosteroid use and intensive care unit-acquired weakness: a systematic review and meta-analysis.Critical care (London, England) · 2018Pooled it
- Prevention of muscle atrophy in ICU patients without nerve injury by neuromuscular electrical stimulation: a randomized controlled study.BMC musculoskeletal disorders · 2022Trial
- The Effect of Early Neuromuscular Electrical Stimulation and Early Mobilization on Preventing the Intensive Care Unit-Acquired Weakness in Lung Cancer Resection Patients: A Randomized Controlled Trial.Technology in cancer research & treatmentTrial
- Effects that passive cycling exercise have on muscle strength, duration of mechanical ventilation, and length of hospital stay in critically ill patients: a randomized clinical trial.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e TisilogiaTrial
- Effect of combined enhanced nutrition and glycemic control on ICU-acquired weakness after lung transplantation: A randomized controlled trial terminated early for futility.Journal of intensive medicine · 2026Article
- ICU-Acquired Weakness: An Unsolved Clinical Problem: A Narrative Review.Journal of clinical medicine · 2026Review
- Muscle Dysfunction and Physical Recovery After Critical Illness.Journal of intensive care medicine · 2026Review
- Muscle mass in critically ill patients: analysis using ultrasound, traditional bioelectrical impedance analysis, and wearable devices: a prospective observational study.European journal of medical research · 2026Article
- Best Evidence Summary on Early Exercise for Prevention of ICU-Acquired Weakness: An Evidence-Based Synthesis.Journal of multidisciplinary healthcare · 2026Review
- Risk factors for ICU-acquired weakness in patients undergoing mechanical ventilation: a systematic review and meta-analysis.Journal of thoracic disease · 2025Article
- The flux of energy in critical illness and the obesity paradox.Physiological reviews · 2025Review
- Evaluating skeletal muscle wasting and weakness in models of critical illness.Clinical science (London, England : 1979) · 2025Review
- Functional independence during hospitalization in patients with intensive care unit-acquired weakness.Journal of physical therapy science · 2025Article
- Effect of Early and Progressive Rehabilitation Protocol on Fatigue, Functional Outcome, and Kinesiophobia in Patients on Non-invasive Ventilation: A Randomized Controlled Trial.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Vitamin D Serum Levels and the Development of Intensive Care Unit-Acquired Weakness: Insights from a COVID-19 Intensive Care Cohort.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Article
- Article
- Review
- Early predictive value of ultrasound measurements of rectus femoris cross-sectional area to diagnose ICU-acquired weakness in patients undergoing invasive mechanical ventilation: a prospective cohort study.European journal of medical research · 2024Article
- Risk factors for ICU-acquired weakness in sepsis patients: A retrospective study of 264 patients.Heliyon · 2024Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundICU-acquired weakness (ICU-AW) has immediate and long-term consequences for critically ill patients. Strategies for the prevention of weakness include modification of known risk factors, such as hyperglycemia and immobility. Intensive insulin therapy (IIT) has been proposed to prevent critical illness polyneuropathy. However, the effect of insulin and early mobilization on clinically apparent weakness is not well known.
methodsThis is a secondary analysis of all patients with mechanical ventilation (N = 104) previously enrolled in a randomized controlled trial of early occupational and physical therapy vs conventional therapy, which evaluated the end point of functional independence. Every patient had IIT and blinded muscle strength testing on hospital discharge to determine the incidence of clinically apparent weakness. The effects of insulin dose and early mobilization on the incidence of ICU-AW were assessed.
resultsOn logistic regression analyses, early mobilization and increasing insulin dose prevented the incidence of ICU-AW (OR, 0.18, P = .001; OR, 0.001, P = .011; respectively) independent of known risk factors for weakness. Early mobilization also significantly reduced insulin requirements to achieve similar glycemic goals as compared with control patients (0.07 units/kg/d vs 0.2 units/kg/d, P < .001).
conclusionsThe duel effect of early mobilization in reducing clinically relevant ICU-AW and promoting euglycemia suggests its potential usefulness as an alternative to IIT.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.