ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2014
Mapping human brain networks with cortico-cortical evoked potentials.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 127 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study: Measure of the Potential Evoked With Electroencephalography and Electrocorticography by Electric Stimulation of the Brain During the Neurosurgery Awakened of the Infiltrative Glioma of Low Grade (OMS Type II)
Neurophysiological Mechanisms of Language Comprehension
Who cites it
127 citing papers in PubMed, 2 syntheses or guidelines pooled it, 243 citations in OpenAlex.
- Methodologies to detect cortico-cortical evoked potentials: a systematic review.Frontiers in human neuroscience · 2025Pooled it
- Neuromonitoring of the language pathways using cortico-cortical evoked potentials: a systematic review and meta-analysis.Neurosurgical review · 2022Pooled it
- Predicting Surgery Targets in Temporal Lobe Epilepsy through Structural Connectome Based Simulations.PLoS computational biology · 2015Trial
- Combined population and patient-specific brain networks predict electrical stimulation propagation.medRxiv : the preprint server for health sciences · 2026Article
- Intracranial Electrical Stimulation of the Superior Temporal Gyrus Evokes Rapid Responses in Human Visual Cortex.The European journal of neuroscience · 2026Article
- Causal Mapping of Bodily Awareness and Mesoscale Circuit Organization in the Human Cingulate and Precuneus.Research square · 2026Article
- Targeting intracranial electrical stimulation to network regions defined within individuals causes network-level effects.Journal of neurophysiology · 2026Article
- Stimulation-evoked orbitofrontal activity as a biomarker for DBS personalization in depression.medRxiv : the preprint server for health sciences · 2026Article
- Optimization of cortico-cortical spectral response analysis parameters for seizure onset zone localization.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- Anti-Seizure Medications Alter Functional and Effective Connectivity as Measured With Intracranial Electroencephalography.Brain and behavior · 2026Article
- Direct electrical stimulation of the human amygdala enhances recognition memory for objects but not scenes.Communications biology · 2026Article
- Monosynaptic connections link functionally similar regions in human cortex.bioRxiv : the preprint server for biology · 2026Article
- A Systematic Characterization of Causal Interactions Between Human Visual Areas.bioRxiv : the preprint server for biology · 2026Article
- Functional Architecture of the Human Insula Revealed by Causal Intracranial Mapping.Research square · 2026Article
- Multimodal evidence for hippocampal engagement and modulation by functional connectivity-guided parietal TMS.Nature communications · 2026Article
- Intrinsic and extrinsic connectivity of the seizure onset zone at rest and during stimulation.medRxiv : the preprint server for health sciences · 2026Article
- Directed cortico-limbic dialogue in the human brain.Nature communications · 2026Article
- A practical preprocessing pipeline for concurrent TMS-iEEG: Critical steps and methodological considerations.NeuroImage · 2026Article
- Case Report: Right frontal periventricular heterotopia underlying secondary network epilepsy with a Lennox-Gastaut phenotype: multimodal SEEG, CCEP, and rs-fMRI evidence.Frontiers in neuroscience · 2026Article
- Parallel encoding of speech in human frontal and temporal lobes.Nature communications · 2025Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
Abstract
The cerebral cortex forms a sheet of neurons organized into a network of interconnected modules that is highly expanded in humans and presumably enables our most refined sensory and cognitive abilities. The links of this network form a fundamental aspect of its organization, and a great deal of research is focusing on understanding how information flows within and between different regions. However, an often-overlooked element of this connectivity regards a causal, hierarchical structure of regions, whereby certain nodes of the cortical network may exert greater influence over the others. While this is difficult to ascertain non-invasively, patients undergoing invasive electrode monitoring for epilepsy provide a unique window into this aspect of cortical organization. In this review, we highlight the potential for cortico-cortical evoked potential (CCEP) mapping to directly measure neuronal propagation across large-scale brain networks with spatio-temporal resolution that is superior to traditional neuroimaging methods. We first introduce effective connectivity and discuss the mechanisms underlying CCEP generation. Next, we highlight how CCEP mapping has begun to provide insight into the neural basis of non-invasive imaging signals. Finally, we present a novel approach to perturbing and measuring brain network function during cognitive processing. The direct measurement of CCEPs in response to electrical stimulation represents a potentially powerful clinical and basic science tool for probing the large-scale networks of the human cerebral cortex.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.