Evidence map›Paper›PMID 25180303›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2014

Functional brain networks: great expectations, hard times and the big leap forward.

David Papo, Massimiliano Zanin, José Angel Pineda-Pardo, Stefano Boccaletti, Javier M Buldú

Open access · bronzeAbstract read
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 95 citations in OpenAlex.

  1. A complex network perspective on brain disease.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
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  13. Regions of Interest as nodes of dynamic functional brain networks.Network neuroscience (Cambridge, Mass.) · 2018
    Article
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  15. Effects of spatial smoothing on functional brain networks.The European journal of neuroscience · 2017
    Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

David PapoCenter for Biomedical Technology, Universidad Politécnica de Madrid, Madrid, Spain papodav@gmail.com.
Massimiliano ZaninFaculdade de Cîencias e Tecnologia, Departamento de Engenharia, Electrotécnica, Universidade Nova de Lisboa, Lisboa, Portugal Innaxis Foundation and Research Institute, Madrid, Spain.
José Angel Pineda-PardoCenter for Biomedical Technology, Universidad Politécnica de Madrid, Madrid, Spain.
Stefano BoccalettiIstituto dei Sistemi Complessi, CNR, Florence, Italy.
Javier M BuldúCenter for Biomedical Technology, Universidad Politécnica de Madrid, Madrid, Spain Complex Systems Group, Universidad Rey Juan Carlos, Móstoles, Spain.
Universidad Politécnica de Madrid · ESInnaxis Foundation & Research Institute · ESInstitute for Complex Systems · IT

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
Localizing functional and pathological networks in epilepsyF31NS080357 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI KELLER, COREY J · 2012 to 2013
$58k
NIGMS NIH HHS T32-GM007288NINDS NIH HHS F31NS080357-01
6 · The paper itself

Abstract

Many physical and biological systems can be studied using complex network theory, a new statistical physics understanding of graph theory. The recent application of complex network theory to the study of functional brain networks has generated great enthusiasm as it allows addressing hitherto non-standard issues in the field, such as efficiency of brain functioning or vulnerability to damage. However, in spite of its high degree of generality, the theory was originally designed to describe systems profoundly different from the brain. We discuss some important caveats in the wholesale application of existing tools and concepts to a field they were not originally designed to describe. At the same time, we argue that complex network theory has not yet been taken full advantage of, as many of its important aspects are yet to make their appearance in the neuroscience literature. Finally, we propose that, rather than simply borrowing from an existing theory, functional neural networks can inspire a fundamental reformulation of complex network theory, to account for its exquisitely complex functioning mode.

Indexed as

ConnectomeModels, NeurologicalBrainHumansNerve NetNeurosciencescomplex networks theoryefficiencyfunctional neuroimagingrobustnesssmall-worldsynchronizability

Identifiers

PMID25180303
PMCPMC4150300
OpenAlexW2121594036

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.