Evidence map›Paper›PMID 25180233›Full record

ArticleThe EMBO journal2014

A near death experience: Shigella manipulates host death machinery to silence innate immunity.

Denise N Bronner, Mary Xd O'Riordan

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Virulence · 2022
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Denise N BronnerDepartment of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.
Mary Xd O'RiordanDepartment of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.

Funding

PREDOCTORAL TRAINING IN GENETICST32GM007544 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 1985 to 2022
$11.3M
NIGMS NIH HHS T32 GM007544
6 · The paper itself

Abstract

Release of mitochondrial contents often triggers inflammation and cell death, and modulating this process can be advantageous to invading pathogens. In this issue of The EMBO Journal, Andree and colleagues reveal new findings that an intracellular bacterial pathogen exploits apoptotic machinery to suppress host immune signaling, yet avoids cell death. This study emphasizes the need to expand our understanding of the roles played by pro‐apoptotic proteins in non‐death scenarios.

Indexed as

AnimalsApoptosis Regulatory ProteinsBH3 Interacting Domain Death Agonist ProteinCarrier ProteinsDysentery, BacillaryFemaleMaleMitochondriaMitochondrial ProteinsShigellaX-Linked Inhibitor of Apoptosis ProteinApoptosis Regulatory ProteinsBH3 Interacting Domain Death Agonist ProteinBid protein, mouseCarrier ProteinsDiablo protein, mouseMitochondrial ProteinsX-Linked Inhibitor of Apoptosis Protein

Identifiers

PMID25180233
PMCPMC4282501

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.