ArticleBioMed research international2014
Novel approach for coexpression analysis of E2F1-3 and MYC target genes in chronic myelogenous leukemia.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Use of pain-related gene features to predict depression by support vector machine model in patients with fibromyalgia.Frontiers in genetics · 2023Article
- The progress of angiogenic factors in the development of leukemias.Intractable & rare diseases research · 2016Review
- Co-expression Pattern Analysis of miR-17-92 Target Genes in Chronic Myelogenous Leukemia.Frontiers in genetics · 2016Article
- Gene network exploration of crosstalk between apoptosis and autophagy in chronic myelogenous leukemia.BioMed research international · 2015Article
- Coexpression Pattern Analysis of NPM1-Associated Genes in Chronic Myelogenous Leukemia.BioMed research international · 2015Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic myelogenous leukemia (CML) is characterized by tremendous amount of immature myeloid cells in the blood circulation. E2F1-3 and MYC are important transcription factors that form positive feedback loops by reciprocal regulation in their own transcription processes. Since genes regulated by E2F1-3 or MYC are related to cell proliferation and apoptosis, we wonder if there exists difference in the coexpression patterns of genes regulated concurrently by E2F1-3 and MYC between the normal and the CML states.
resultsWe proposed a method to explore the difference in the coexpression patterns of those candidate target genes between the normal and the CML groups. A disease-specific cutoff point for coexpression levels that classified the coexpressed gene pairs into strong and weak coexpression classes was identified. Our developed method effectively identified the coexpression pattern differences from the overall structure. Moreover, we found that genes related to the cell adhesion and angiogenesis properties were more likely to be coexpressed in the normal group when compared to the CML group.
conclusionOur findings may be helpful in exploring the underlying mechanisms of CML and provide useful information in cancer treatment.
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