ArticleeLife2014
Cross-synaptic synchrony and transmission of signal and noise across the mouse retina.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Inferring effective neuronal circuits via network flux counting.PLoS computational biology · 2026Article
- Origin and functional impact of early nonlinearities in primate retina.bioRxiv : the preprint server for biology · 2026Article
- Induction of a Müller Glial Cell-Specific Protective Pathway Safeguards the Retina From Diabetes-Induced Damage.Diabetes · 2025Article
- Image Analysis Routines for Quantification of Synaptic Density and Connectivity.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Ancient origin of the rod bipolar cell pathway in the vertebrate retina.Nature ecology & evolution · 2024Article
- Defining morphologically and genetically distinct GABAergic/cholinergic amacrine cell subtypes in the vertebrate retina.PLoS biology · 2024Article
- A presynaptic source drives differing levels of surround suppression in two mouse retinal ganglion cell types.Nature communications · 2024Article
- Ancient origin of the rod bipolar cell pathway in the vertebrate retina.Research square · 2023Article
- Ancient origin of the rod bipolar cell pathway in the vertebrate retina.bioRxiv : the preprint server for biology · 2023Article
- Hierarchical partner selection shapes rod-cone pathway specificity in the inner retina.iScience · 2022Article
- Inhibitory inputs to an inhibitory interneuron: Spontaneous postsynaptic currents and GABAThe European journal of neuroscience · 2022Article
- Retinal horizontal cells use different synaptic sites for global feedforward and local feedback signaling.Current biology : CB · 2022Article
- Dendro-somatic synaptic inputs to ganglion cells contradict receptive field and connectivity conventions in the mammalian retina.Current biology : CB · 2022Article
- Transient expression of a GABA receptor subunit during early development is critical for inhibitory synapse maturation and function.Current biology : CB · 2021Article
- GABAeLife · 2021Article
- Article
- Differential Contribution of Gap Junctions to the Membrane Properties of ON- and OFF-Bipolar Cells of the Rat Retina.Cellular and molecular neurobiology · 2021Article
- Connectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision.eLife · 2020Article
- Extrasynaptic NMDA Receptors on Rod Pathway Amacrine Cells: Molecular Composition, Activation, and Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The dynamic receptive fields of retinal ganglion cells.Progress in retinal and eye research · 2018Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Cross-synaptic synchrony--correlations in transmitter release across output synapses of a single neuron--is a key determinant of how signal and noise traverse neural circuits. The anatomical connectivity between rod bipolar and A17 amacrine cells in the mammalian retina, specifically that neighboring A17s often receive input from many of the same rod bipolar cells, provides a rare technical opportunity to measure cross-synaptic synchrony under physiological conditions. This approach reveals that synchronization of rod bipolar cell synapses is near perfect in the dark and decreases with increasing light level. Strong synaptic synchronization in the dark minimizes intrinsic synaptic noise and allows rod bipolar cells to faithfully transmit upstream signal and noise to downstream neurons. Desynchronization in steady light lowers the sensitivity of the rod bipolar output to upstream voltage fluctuations. This work reveals how cross-synaptic synchrony shapes retinal responses to physiological light inputs and, more generally, signaling in complex neural networks.
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Registered trials
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