Evidence map›Paper›PMID 25180040›Full record

ArticleStem cells international2014

Acupoint injection of autologous stromal vascular fraction and allogeneic adipose-derived stem cells to treat hip dysplasia in dogs.

Camila Marx, Maiele Dornelles Silveira, Isabel Selbach, Ariel Silveira da Silva, Luisa Maria Gomes de Macedo Braga, Melissa Camassola, Nance Beyer Nardi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 81 citations in OpenAlex.

  1. Trial
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  7. The Use of Stromal Vascular Fraction in Long Bone Defect Healing in Sheep.Animals : an open access journal from MDPI · 2023
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  15. An Outstanding Role of Adipose Tissue in Canine Stem Cell Therapy.Animals : an open access journal from MDPI · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Camila MarxLaboratory of Stem Cells and Tissue Engineering, Universidade Luterana do Brasil, 92425-900 Canoas, RS, Brazil.
Maiele Dornelles SilveiraLaboratory of Stem Cells and Tissue Engineering, Universidade Luterana do Brasil, 92425-900 Canoas, RS, Brazil.
Isabel SelbachClinivetis Clinica Veterinaria, 93310-500 Novo Hamburgo, RS, Brazil.
Ariel Silveira da SilvaLaboratory of Stem Cells and Tissue Engineering, Universidade Luterana do Brasil, 92425-900 Canoas, RS, Brazil.
Luisa Maria Gomes de Macedo BragaCenter for Experimental Biological Models, Pontificia Universidade Catolica do Rio Grande do Sul, 90619-900 Porto Alegre, RS, Brazil.
Melissa CamassolaLaboratory of Stem Cells and Tissue Engineering, Universidade Luterana do Brasil, 92425-900 Canoas, RS, Brazil.
Nance Beyer NardiLaboratory of Stem Cells and Tissue Engineering, Universidade Luterana do Brasil, 92425-900 Canoas, RS, Brazil.
Universidade Luterana do Brasil · BRAssociação Brasileira de Oncologia Veterinária · BRPontifícia Universidade Católica do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cells isolated from adipose tissue show great therapeutic potential in veterinary medicine, but some points such as the use of fresh or cultured cells and route of administration need better knowledge. This study aimed to evaluate the effect of autologous stromal vascular fraction (SVF, n = 4) or allogeneic cultured adipose-derived stem cells (ASCs, n = 5) injected into acupuncture points in dogs with hip dysplasia and weak response to drug therapy. Canine ASCs have proliferation and differentiation potential similar to ASCs from other species. After the first week of treatment, clinical evaluation showed marked improvement compared with baseline results in all patients treated with autologous SVF and three of the dogs treated with allogeneic ASCs. On days 15 and 30, all dogs showed improvement in range of motion, lameness at trot, and pain on manipulation of the joints, except for one ASC-treated patient. Positive results were more clearly seen in the SVF-treated group. These results show that autologous SVF or allogeneic ASCs can be safely used in acupoint injection for treating hip dysplasia in dogs and represent an important therapeutic alternative for this type of pathology. Further studies are necessary to assess a possible advantage of SVF cells in treating joint diseases.

Identifiers

PMID25180040
PMCPMC4144304
OpenAlexW2060114719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.