ArticleRespiratory physiology & neurobiology2014
The effect of adrenal medullectomy on metabolic responses to chronic intermittent hypoxia.
Article in Respiratory physiology & neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Obstructive Sleep Apnea Dynamically Increases Nocturnal Plasma Free Fatty Acids, Glucose, and Cortisol During Sleep.The Journal of clinical endocrinology and metabolism · 2017Trial
- Intermittent hypoxia training in prediabetes patients: Beneficial effects on glucose homeostasis, hypoxia tolerance and gene expression.Experimental biology and medicine (Maywood, N.J.) · 2017Trial
- Carotid body denervation improves hyperglycemia in obese mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Investigating the Relationship between Obstructive Sleep Apnoea, Inflammation and Cardio-Metabolic Diseases.International journal of molecular sciences · 2023Review
- Murine models of sleep apnea: functional implications of altered macrophage polarity and epigenetic modifications in adipose and vascular tissues.Metabolism: clinical and experimental · 2018Review
- Sleep apnea, metabolic disease, and the cutting edge of therapy.Metabolism: clinical and experimental · 2018Review
- Recognition and treatment of sleep-disordered breathing: an important component of chronic disease management.Journal of translational medicine · 2017Review
- Adipose tissue inflammation by intermittent hypoxia: mechanistic link between obstructive sleep apnoea and metabolic dysfunction.The Journal of physiology · 2017Review
- Effect of adrenal medullectomy on metabolic responses to chronic intermittent hypoxia in the frequently sampled intravenous glucose tolerance test.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Redistribution of adrenomedullary nicotinic acetylcholine receptor subunits and the effect on circulating epinephrine levels in a murine model of acute asthma.International journal of molecular medicine · 2017Article
- Inhibition of Lipolysis Ameliorates Diabetic Phenotype in a Mouse Model of Obstructive Sleep Apnea.American journal of respiratory cell and molecular biology · 2016Article
- Biological plausibility linking sleep apnoea and metabolic dysfunction.Nature reviews. Endocrinology · 2016Review
- Acute Ozone-Induced Pulmonary and Systemic Metabolic Effects Are Diminished in Adrenalectomized Rats.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Translational approaches to understanding metabolic dysfunction and cardiovascular consequences of obstructive sleep apnea.American journal of physiology. Heart and circulatory physiology · 2015Review
- Insulin resistance, glucose intolerance and diabetes mellitus in obstructive sleep apnoea.Journal of thoracic disease · 2015Review
- Inflammation in sleep apnea: an update.Reviews in endocrine & metabolic disorders · 2015Review
- The impact of sleep disorders on glucose metabolism: endocrine and molecular mechanisms.Diabetology & metabolic syndrome · 2015Article
- Intermittent hypoxia-induced glucose intolerance is abolished by α-adrenergic blockade or adrenal medullectomy.American journal of physiology. Endocrinology and metabolism · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Obstructive sleep apnea causes intermittent hypoxia (IH) and is associated with insulin resistance and type 2 diabetes. IH increases plasma catecholamine levels, which may increase insulin resistance and suppress insulin secretion. The objective of this study was to determine if adrenal medullectomy (MED) prevents metabolic dysfunction in IH. MED or sham surgery was performed in 60 male C57BL/6J mice, which were then exposed to IH or control conditions (intermittent air) for 6 weeks. IH increased plasma epinephrine and norepinephrine levels, increased fasting blood glucose and lowered basal and glucose-stimulated insulin secretion. MED decreased baseline epinephrine and prevented the IH induced increase in epinephrine, whereas the norepinephrine response remained intact. MED improved glucose tolerance in mice exposed to IH, attenuated the impairment in basal and glucose-stimulated insulin secretion, but did not prevent IH-induced fasting hyperglycemia or insulin resistance. We conclude that the epinephrine release from the adrenal medulla during IH suppresses insulin secretion causing hyperglycemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.