SynthesisEuropean journal of epidemiology2014
Subclinical thyroid dysfunction and the risk of stroke: a systematic review and meta-analysis.
Synthesis in European journal of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 5 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Pooled it
- Pooled it
- The Association of Overt and Subclinical Hyperthyroidism with the Risk of Cardiovascular Events and Cardiovascular Mortality: Meta-Analysis and Systematic Review of Cohort Studies.Endocrinology and metabolism (Seoul, Korea) · 2020Pooled it
- Hypothyroidism and related diseases: a methodological quality assessment of meta-analysis.BMJ open · 2019Pooled it
- Thyroid Function Within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis.The Journal of clinical endocrinology and metabolism · 2016Pooled it
- The relationship between thyroid dysfunction, cardiovascular morbidity and mortality in type 2 diabetes: The Fremantle Diabetes Study Phase II.Acta diabetologica · 2022Trial
- Thyroid dysfunction and cardiovascular disease.European heart journal · 2026Review
- Association between thyroid function and 10-year cardiovascular disease risk of patients with diabetes: a cross-sectional study using KNHANES 2013-2014.Journal of Yeungnam medical science · 2026Article
- Hypothyroidism: playing the cardiometabolic risk concerto.Thyroid research · 2025Review
- Mendelian Randomization Study Investigating the Causal Relationship Between Thyroid Dysfunction and Cerebral Infarction.Brain and behavior · 2024Article
- Physical activity affects dysthyreosis by thyroid hormones sensitivity: a population-based study.Frontiers in endocrinology · 2024Article
- Thyroid and cardiovascular diseases.Turkish journal of medical sciences · 2024Review
- Hypothyroidism and Cardiovascular Disease: A Review.Cureus · 2024Review
- Association Between Serum Thyroid Measurements and Hyperhomocysteinemia in Euthyroid Subjects: A Retrospective Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Increased 10-year cardiovascular disease risk in depressed patients with coexisting subclinical hypothyroidism.Frontiers in psychiatry · 2023Article
- Association of Mild Thyroid Dysfunction and Adverse Prognosis Among Chinese Patients With Acute ST Segment Elevation Myocardial Infarction.Frontiers in endocrinology · 2022Article
- Decision Making in Subclinical Thyroid Disease.The Medical clinics of North America · 2021Review
- Hypothyroidism and risks of cerebrovascular complications among patients with head and neck cancer after radiotherapy.BMC neurology · 2021Article
- Long-term cardiovascular and cerebrovascular morbidity in Israeli thyroid cancer survivors.Endocrine connections · 2019Article
- Thyroid Function, Cardiovascular Risk Factors, and Incident Atherosclerotic Cardiovascular Disease: The Atherosclerosis Risk in Communities (ARIC) Study.The Journal of clinical endocrinology and metabolism · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subclinical thyroid dysfunction has been associated with coronary heart disease, but the risk of stroke is unclear. Our aim is to combine the evidence on the association between subclinical thyroid dysfunction and the risk of stroke in prospective cohort studies. We searched Medline (OvidSP), Embase, Web-of-Science, Pubmed Publisher, Cochrane and Google Scholar from inception to November 2013 using a cohort filter, but without language restriction or other limitations. Reference lists of articles were searched. Two independent reviewers screened articles according to pre-specified criteria and selected prospective cohort studies with baseline thyroid function measurements and assessment of stroke outcomes. Data were derived using a standardized data extraction form. Quality was assessed according to previously defined quality indicators by two independent reviewers. We pooled the outcomes using a random-effects model. Of 2,274 articles screened, six cohort studies, including 11,309 participants with 665 stroke events, met the criteria. Four of six studies provided information on subclinical hyperthyroidism including a total of 6,029 participants and five on subclinical hypothyroidism (n = 10,118). The pooled hazard ratio (HR) was 1.08 (95 % CI 0.87-1.34) for subclinical hypothyroidism (I (2) of 0 %) and 1.17 (95 % CI 0.54-2.56) for subclinical hyperthyroidism (I (2) of 67 %) compared to euthyroidism. Subgroup analyses yielded similar results. Our systematic review provides no evidence supporting an increased risk for stroke associated with subclinical thyroid dysfunction. However, the available literature is insufficient and larger datasets are needed to perform extended analyses. Also, there were insufficient events to exclude clinically significant risk from subclinical hyperthyroidism, and more data are required for subgroup analyses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.