ArticleIrish journal of medical science2015
Increases in interleukin-6 and interferon-gamma levels is progressive in immature rats with varicocele.
Article in Irish journal of medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Advances in immunological research on male infertility.Frontiers in reproductive health · 2026Review
- Research advances in inflammation and oxidative stress in varicocele-induced male infertility: a narrative review.Asian journal of andrology · 2025Review
- The effect of astaxanthin after varicocele surgery on antioxidant status and semen quality in infertile men: A triple-blind randomized clinical trial.Food science & nutrition · 2024Article
- Anti-inflammatory and anti-oxidant action of tadalafil in testicular regeneration process after heat stress.Animal reproduction · 2024Article
- The time course of nod-like receptor family pyrin domain containing 3 inflammasome complex expressions in the testis tissue of an experimental varicocele rat model: An experimental study.International journal of reproductive biomedicine · 2023Article
- Zishen Yutai Pill improves sperm quality and reduces testicular inflammation in experimental varicocele rats.Heliyon · 2023Article
- Microbiology and immune mechanisms associated with male infertility.Frontiers in immunology · 2023Review
- Varicocele and testicular cord torsion: immune testicular microenvironment imbalance.Frontiers in cell and developmental biology · 2023Review
- Role of Oxidative Stress in Varicocele.Frontiers in genetics · 2022Review
- Varicocele-Mediated Male Infertility: From the Perspective of Testicular Immunity and Inflammation.Frontiers in immunology · 2021Review
- Presence of The NLRP3 Inflammasome Components in Semen of Varicocele Patients.International journal of fertility & sterility · 2020Article
- The ameliorative effect of monotropein, astragalin, and spiraeoside on oxidative stress, endoplasmic reticulum stress, and mitochondrial signaling pathway in varicocelized rats.BMC complementary and alternative medicine · 2019Article
- The Effect of Schisandra chinensis Baillon on Cross-Talk between Oxidative Stress, Endoplasmic Reticulum Stress, and Mitochondrial Signaling Pathway in Testes of Varicocele-Induced SD Rat.International journal of molecular sciences · 2019Article
- Resveratrol decreases apoptosis and NLRP3 complex expressions in experimental varicocele rat model.Iranian journal of basic medical sciences · 2018Article
- Spermatozoal Fractalkine Signaling Pathway Is Upregulated in Subclinical Varicocele Patients with Normal Seminogram and Low-Level Leucospermia.Advances in urology · 2017Article
- More work needed in examining the relationship between mean platelet volume and inflammation in varicocele pathophysiology.Canadian Urological Association journal = Journal de l'Association des urologues du CanadaArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPre-pubertal varicocele can result in hypotrophy of testes, progressive deterioration of Sertoli cells and spermatogonia cell number, decrease in seminiferous diameter and cause to sperm damage.
aimsBecause of detrimental time-dependent effects of varicocele, this study describes the effects of varicocele on the levels of interleukin-6 (IL-6) and interferon-gamma in serum and testis tissue, seminiferous tubules diameter, number of Sertoli and spermatogonia cells, testis and epididymis weight and volume and sperm indices in immature rats.
methodsThirty-six immature rats (5-6 weeks) were assigned into six groups: three sham groups and three varicocele groups. Serum, testis, and sperm samples were collected at 9, 11, and 13 weeks after induction of varicocele or sham operation to evaluate histological parameters and levels of cytokines.
resultsVaricocele significantly caused an increase in serum and testis IL-6 and interferon-gamma, compared to related sham groups and previous varicocele groups (P < 0.05). Varicocele significantly decreased Sertoli cells and spermatogonia cell number with increasing varicocele time (P < 0.05). In the evaluation of seminiferous tubules diameter, the external, internal, and epithelium diameter were decreased compared to sham-related groups and previous varicocele groups. In the all varicocele groups, all types of sperm motility decreased compared to the related sham-operated group (P < 0.05).
conclusionsThis study suggests varicocele has a detrimental, time-dependent effect on cytokines levels and decreases Sertoli cells, spermatogonia cell number, seminiferous tubules diameter, and sperm indices.
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