ArticleBMC plant biology2014
A small XY chromosomal region explains sex determination in wild dioecious V. vinifera and the reversal to hermaphroditism in domesticated grapevines.
Article in BMC plant biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Plant sex chromosomes defy evolutionary models of expanding recombination suppression and genetic degeneration.Nature plants · 2021Pooled it
- SBP-Box Transcription Factor JcSPL9 Regulates Both Seed Yield and Oil Content in the Biofuel Plant Jatropha curcas.Plant biotechnology journal · 2026Article
- Characterization and transcriptomic analysis provide novel insights into the sexual differentiation of the dioecious plant Bama Huoma (Cannabis sativa).BMC plant biology · 2025Article
- Gender specific SNP markers in Coscinium fenestratum (Gaertn.) Colebr. for resource augmentation.Molecular biology reports · 2024Article
- Evolution of sex in crops: recurrent scrap and rebuild.Breeding science · 2023Article
- A genome-wide association and prediction study in grapevine deciphers the genetic architecture of multiple traits and identifies genes under many new QTLs.G3 (Bethesda, Md.) · 2022Article
- Identification of Sex Differentiation-Related microRNAs in Spinach Female and Male Flower.International journal of molecular sciences · 2022Article
- Berry Anthocyanin, Acid, and Volatile Trait Analyses in a Grapevine-Interspecific F2 Population Using an Integrated GBS and rhAmpSeq Genetic Map.Plants (Basel, Switzerland) · 2022Article
- Reinvention of hermaphroditism via activation of a RADIALIS-like gene in hexaploid persimmon.Nature plants · 2022Article
- Genetic changes in the genusFrontiers in plant science · 2022Review
- VviPLATZ1 is a major factor that controls female flower morphology determination in grapevine.Nature communications · 2021Article
- The timing of genetic degeneration of sex chromosomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Detecting sex-linked genes using genotyped individuals sampled in natural populations.Genetics · 2021Article
- Multiple independent recombinations led to hermaphroditism in grapevine.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Diversity of Plant Sex Chromosomes Highlighted through Advances in Genome Sequencing.Genes · 2021Review
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- Comparative transcriptome analysis of male and female flowers in Spinacia oleracea L.BMC genomics · 2020Article
- Portuguese wild grapevine genome re-sequencing (Vitis vinifera sylvestris).Scientific reports · 2020Article
- The wild grape genome sequence provides insights into the transition from dioecy to hermaphroditism during grape domestication.Genome biology · 2020Article
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn Vitis vinifera L., domestication induced a dramatic change in flower morphology: the wild sylvestris subspecies is dioecious while hermaphroditism is largely predominant in the domesticated subsp. V. v. vinifera. The characterisation of polymorphisms in genes underlying the sex-determining chromosomal region may help clarify the history of domestication in grapevine and the evolution of sex chromosomes in plants. In the genus Vitis, sex determination is putatively controlled by one major locus with three alleles, male M, hermaphrodite H and female F, with an allelic dominance M > H > F. Previous genetic studies located the sex locus on chromosome 2. We used DNA polymorphisms of geographically diverse V. vinifera genotypes to confirm the position of this locus, to characterise the genetic diversity and traces of selection in candidate genes, and to explore the origin of hermaphroditism.
resultsIn V. v. sylvestris, a sex-determining region of 154.8 kb, also present in other Vitis species, spans less than 1% of chromosome 2. It displays haplotype diversity, linkage disequilibrium and differentiation that typically correspond to a small XY sex-determining region with XY males and XX females. In male alleles, traces of purifying selection were found for a trehalose phosphatase, an exostosin and a WRKY transcription factor, with strikingly low polymorphism levels between distant geographic regions. Both diversity and network analysis revealed that H alleles are more closely related to M than to F alleles.
conclusionsHermaphrodite alleles appear to derive from male alleles of wild grapevines, with successive recombination events allowing import of diversity from the X into the Y chromosomal region and slowing down the expansion of the region into a full heteromorphic chromosome. Our data are consistent with multiple domestication events and show traces of introgression from other Asian Vitis species into the cultivated grapevine gene pool.
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