Evidence map›Paper›PMID 25179402›Full record

ArticleBMB reports2014

YAC tripeptide of epidermal growth factor promotes the proliferation of HaCaT keratinocytes through activation of EGFR.

Yeon Ho Yoo, Yu Ri Kim, Min Seo Kim, Kyoung-Jin Lee, Kyeong Han Park, Jang-Hee Hahn

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMB reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yeon Ho YooDepartment of Anatomy and Cell Biology, School of Medicine, Kangwon National University, Chuncheon 200-701, Korea.
Yu Ri KimDepartment of Anatomy and Cell Biology, School of Medicine, Kangwon National University, Chuncheon 200-701, Korea.
Min Seo KimDepartment of Anatomy and Cell Biology, School of Medicine, Kangwon National University, Chuncheon 200-701, Korea.
Kyoung-Jin LeeDepartment of Anatomy and Cell Biology, School of Medicine, Kangwon National University, Chuncheon 200-701, Korea.
Kyeong Han ParkDepartment of Anatomy and Cell Biology, School of Medicine, Kangwon National University, Chuncheon 200-701, Korea.
Jang-Hee HahnDepartment of Anatomy and Cell Biology, School of Medicine, Kangwon National University, Chuncheon 200-701, Korea.
Kangwon National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epidermal growth factor (EGF) is known to play key roles in skin regeneration and wound-healing. Here, we demonstrate that Pep2-YAC, a tripeptide covering residues 29-31 in the B loop of EGF, promotes the proliferation of HaCaT keratinocytes with activity comparable to EGF. The treatment of HaCaT cells with Pep2-YAC induced phosphorylation, internalization, and degradation of EGFR and organization of signaling complexes, which consist of Grb2, Gab1, SHP2, and PI3K. In addition, it stimulated the phosphorylation of ERK1/2 at Thr 202/Tyr 204 and of Akt1 at Ser 473 and the nuclear translocation of EGFR, STAT3, c-Jun, and c-Fos. These results suggest that Pep2-YAC may be useful as a therapeutic agent for skin regeneration and wound-healing as an EGFR agonist.

Indexed as

Adaptor Proteins, Signal TransducingAmino Acid SequenceCell LineCell NucleusCell ProliferationEpidermal Growth FactorErbB ReceptorsExtracellular Signal-Regulated MAP KinasesHumansKeratinocytesMolecular Sequence DataOligopeptidesPeptidesProtein TransportProtein Tyrosine Phosphatase, Non-Receptor Type 11Proto-Oncogene Proteins c-aktAdaptor Proteins, Signal TransducingEpidermal Growth FactorErbB ReceptorsExtracellular Signal-Regulated MAP KinasesGAB1 protein, humanOligopeptidesPeptidesProtein Tyrosine Phosphatase, Non-Receptor Type 11Proto-Oncogene Proteins c-aktTranscription Factorstyrosyl-alanyl-cysteine

Identifiers

PMID25179402
PMCPMC4261517
OpenAlexW1964456728

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.