Trial reportTrials2014
MR CLEAN, a multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke in the Netherlands: study protocol for a randomized controlled trial.
Trial report in Trials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
110 citing papers in PubMed, 5 syntheses or guidelines pooled it, 549 citations in OpenAlex.
- Safety of mechanical thrombectomy in pediatric acute ischemic stroke: a systematic review and meta-analysis.Neuroradiology · 2025Pooled it
- Hyperacute stenting and angioplasty for acute extracranial non-tandem internal carotid artery strokes within the first 48 h: A 20-year experience and a systematic review and meta-analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Pooled it
- Systematic Review of Existing Stroke Guidelines: Case for a Change.BioMed research international · 2022Pooled it
- Endovascular treatment versus medical care alone for ischaemic stroke: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2016Pooled it
- Pooled it
- Isolation and identification of leukocyte populations in intracranial blood collected during mechanical thrombectomy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Trial
- Added Value of a Blinded Outcome Adjudication Committee in an Open-Label Randomized Stroke Trial.Stroke · 2022Trial
- Two-way comparison of brain perfusion image processing software for patients with acute ischemic strokes in real-world.Neuroradiology · 2022Trial
- Quantified health and cost effects of faster endovascular treatment for large vessel ischemic stroke patients in the Netherlands.Journal of neurointerventional surgery · 2021Trial
- Association of Reperfusion With Brain Edema in Patients With Acute Ischemic Stroke: A Secondary Analysis of the MR CLEAN Trial.JAMA neurology · 2018Trial
- Collateral status and tissue outcome after intra-arterial therapy for patients with acute ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Trial
- Value of Thrombus CT Characteristics in Patients with Acute Ischemic Stroke.AJNR. American journal of neuroradiology · 2017Trial
- Selection of patients for intra-arterial treatment for acute ischaemic stroke: development and validation of a clinical decision tool in two randomised trials.BMJ (Clinical research ed.) · 2017Trial
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- Endovascular therapy in acute ischaemic stroke patients with prestroke dependency-an EVA-TRISP cohort study.European stroke journal · 2026Observational
- Functional outcomes after reperfusion therapy for acute ischemic stroke: Is there a modifying effect of renin-angiotensin-aldosterone system inhibition?Neurosurgical review · 2026Article
- Periprocedural Hypotension and Functional Outcomes in Ischemic Stroke Patients Undergoing Mechanical Thrombectomy.Stroke (Hoboken, N.J.) · 2025Article
- Heart vs. Brain in a Warzone: The Effects of War on Acute Cardiovascular and Neurological Emergencies.Diagnostics (Basel, Switzerland) · 2025Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndovascular or intra-arterial treatment (IAT) increases the likelihood of recanalization in patients with acute ischemic stroke caused by a proximal intracranial arterial occlusion. However, a beneficial effect of IAT on functional recovery in patients with acute ischemic stroke remains unproven. The aim of this study is to assess the effect of IAT on functional outcome in patients with acute ischemic stroke. Additionally, we aim to assess the safety of IAT, and the effect on recanalization of different mechanical treatment modalities. METHODS/
designA multicenter randomized clinical trial with blinded outcome assessment. The active comparison is IAT versus no IAT. IAT may consist of intra-arterial thrombolysis with alteplase or urokinase, mechanical treatment or both. Mechanical treatment refers to retraction, aspiration, sonolysis, or use of a retrievable stent (stent-retriever). Patients with a relevant intracranial proximal arterial occlusion of the anterior circulation, who can be treated within 6 hours after stroke onset, are eligible. Treatment effect will be estimated with ordinal logistic regression (shift analysis); 500 patients will be included in the trial for a power of 80% to detect a shift leading to a decrease in dependency in 10% of treated patients. The primary outcome is the score on the modified Rankin scale at 90 days. Secondary outcomes are the National Institutes of Health stroke scale score at 24 hours, vessel patency at 24 hours, infarct size on day 5, and the occurrence of major bleeding during the first 5 days. DISCUSSION: If IAT leads to a 10% absolute reduction in poor outcome after stroke, careful implementation of the intervention could save approximately 1% of all new stroke cases from death or disability annually.
trial registrationNTR1804 (7 May 2009)/ISRCTN10888758 (24 July 2012).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.