ReviewBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals2015
Chopping off the chondrocyte proteome.
Review in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Ultrasound Phenotype-Based Approach to Treatment Choice in Osteoarthritis.Life (Basel, Switzerland) · 2025Article
- Two-year post-distraction cartilage-related structural improvement is accompanied by increased serum full-length SIRT1.Arthritis research & therapy · 2024Article
- Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence.Annals of the rheumatic diseases · 2020Article
- Emerging Technologies and Platforms for the Immunodetection of Multiple Biochemical Markers in Osteoarthritis Research and Therapy.Frontiers in medicine · 2020Review
- Cell Therapy and Tissue Engineering Approaches for Cartilage Repair and/or Regeneration.International journal of stem cells · 2015Review
- Biomarkers of (osteo)arthritis.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2015Article
- Detecting early stage osteoarthritis by optical coherence tomography?Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The progressive nature of osteoarthritis is manifested by the dynamic increase of degenerated articular cartilage, which is one of the major characteristics of this debilitating disease. As articular chondrocytes become exposed to inflammatory stress they enter a pro-catabolic state, which leads to the secretion and activation of a plethora of proteases. In aim to detect the disease before massive areas of cartilage are destroyed, various protein and non-protein biomarkers have been examined in bodily fluids and correlated with disease severity. This review will discuss the widely research extracellular degraded products as well as products generated by affected cellular pathways upon increased protease activity. While extracellular components could be more abundant, cleaved cellular proteins are less abundant and are suggested to possess a significant effect on cell metabolism and cartilage secretome. Subtle changes in cell secretome could potentially act as indicators of the chondrocyte metabolic and biological state. Therefore, it is envisioned that combined biomarkers composed of both cell and extracellular-degraded secretome could provide a valuable platform for testing drug efficacy to halt disease progression at its early stages.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.