ArticleBMC ophthalmology2014
Characterization of macular thickness changes in Leber's hereditary optic neuropathy by optical coherence tomography.
Article in BMC ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Efficacy and safety of intravitreal rAAV2-ND4 therapy for Leber's hereditary optic neuropathy.Eye (London, England) · 2025Article
- The rAAV2-ND1 gene therapy for Leber hereditary optic neuropathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Early Macular Ganglion Cell Loss in Leber Hereditary Optic Neuropathy, an Optical Coherence Tomography Biomarker to Differentiate Optic Neuritis.Journal of clinical medicine · 2025Article
- Ganglion Cell Complex Thickness and Visual Function in Chronic Leber Hereditary Optic Neuropathy.Investigative ophthalmology & visual science · 2024Article
- The Relative Preservation of the Central Retinal Layers in Leber Hereditary Optic Neuropathy.Journal of clinical medicine · 2022Article
- Arterial sheathing in Leber hereditary optic neuropathy.American journal of ophthalmology case reports · 2022Article
- Clinical Characteristics of Methanol-Induced Optic Neuropathy: Correlation between Aetiology and Clinical Findings.Journal of ophthalmology · 2022Article
- Changes in Visual Function and Correlations with Inner Retinal Structure in Acute and Chronic Leber's Hereditary Optic Neuropathy Patients after Treatment with Idebenone.Journal of clinical medicine · 2021Article
- Electrophysiological and Structural Changes in Chinese Patients with LHON.Journal of ophthalmology · 2020Article
- Structural impairment patterns in peripapillary retinal fiber layer and retinal ganglion cell layer in mitochondrial optic neuropathies.International journal of ophthalmology · 2018Article
- Long-term outcomes of gene therapy for the treatment of Leber's hereditary optic neuropathy.EBioMedicine · 2016Article
- The Optical Coherence Tomographic Profile of Leber Hereditary Optic Neuropathy.Neuro-ophthalmology (Aeolus Press) · 2016Article
- A retrospective analysis of characteristics of visual field damage in patients with Leber's hereditary optic neuropathy.SpringerPlus · 2016Article
- Leber hereditary optic neuropathy: current perspectives.Clinical ophthalmology (Auckland, N.Z.) · 2015Review
- The role of Optical Coherence Tomography in optic neuropathies.Romanian journal of ophthalmologyReview
- Leber's hereditary optic neuropathy - Case report.Romanian journal of ophthalmologyArticle
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTo characterize macular thickness (MT) changes in Leber's hereditary optic neuropathy (LHON) patients by cirrus HD-optical coherence tomography (OCT), and to study the correlation between MT and best corrected visual acuity (BCVA).
methodsFifty-two eyes from 52 consecutive LHON patients and 14 eyes from 14 age- and sex-matched healthy controls were scanned by OCT. Affected eyes were classified into five groups according to disease duration (1st group: ≤3 months; 2nd group: 3-6 months; 3rd group: 6-9 months; 4th group: 9-12 months; and 5th group: >12 months). MT was compared and analyzed. The correlation between BCVA and MT was calculated.
resultsLess than six months after LHON onset, the cube average thickness (CAT) and the MT in the superior, nasal, inferior, and temporal quadrants of the inner ring and the MT in the nasal quadrant of the outer ring were decreased (P < 0.005); at 3-6 months onset, the MT of the temporal quadrants of the outer ring was decreased (P = 0.045); after 6 months, the MT was significantly thinner in all measurements (P < 0.01) except for the central ring. The BCVA was significantly different between each group and controls (P < 0.05), but there was no significant correlation among the five groups (P = 0.666). There was no significant correlation between the BCVA and CAT (P = 0.893).
conclusionsThe MT thinned before the retinal nerve fiber layer and this occurred with a particular sequence. Our results provide potential diagnostic information for LHON.
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