ArticleBMC complementary and alternative medicine2014
Antidepressant-like effects of the hydroalcoholic extracts of Hemerocallis citrina and its potential active components.
Article in BMC complementary and alternative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 62 citations in OpenAlex.
- 3-O-p-coumaroylquinic acid and 4-O-p-coumaroylquinic acid from Hemerocallis citrina Baroni exert antidepressant effects via CA/Dopa/DA/NE and PKA/CREB/BDNF signaling pathways.NPJ science of food · 2026Article
- Androgens alleviate the depression-like phenotype in female mice by inhibiting AVPR1a in the hippocampal brain region.Molecular medicine (Cambridge, Mass.) · 2025Article
- Therapeutic Effects ofInternational journal of molecular sciences · 2025Article
- Integrated metabolomic and transcriptomic analysis revealed the transition of functional components in edible flower buds ofFood chemistry: X · 2024Article
- Anti-depression molecular mechanism elucidation of the phytochemicals in edible flower ofFood science & nutrition · 2024Article
- Comparative Analysis of the Sedative and Hypnotic Effects among Various Parts ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Review
- An Investigation of the Anti-Depressive Properties of Phenylpropanoids and Flavonoids inMolecules (Basel, Switzerland) · 2022Article
- Antidepressant-like activity, active components and related mechanism ofFrontiers in pharmacology · 2022Article
- Study and Experimental Validation of the Functional Components and Mechanisms ofFoods (Basel, Switzerland) · 2021Article
- Study on the Sleep-Improvement Effects ofFoods (Basel, Switzerland) · 2021Article
- A Combined Network Pharmacology and Molecular Docking Approach to Investigate Candidate Active Components and Multitarget Mechanisms of Hemerocallis Flowers on Antidepressant Effect.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Phenolic Composition and Skin-Related Properties of the Aerial Parts Extract of DifferentAntioxidants (Basel, Switzerland) · 2020Article
- Characterization ofFrontiers in plant science · 2020Article
- Recent Studies on Anti-Depressant Bioactive Substances in Selected Species from the GeneraPharmaceuticals (Basel, Switzerland) · 2019Review
- Remarkable rutin-rich Hypericum capitatum extract exhibits anti-inflammatory effects on turpentine oil-induced inflammation in rats.BMC complementary and alternative medicine · 2019Article
- Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents.Scientifica · 2018Review
- Antipsychotic-like activity of scopoletin and rutin against the positive symptoms of schizophrenia in mouse models.Experimental animals · 2017Article
- Effects of phenolic constituents of daylily flowers on corticosterone- and glutamate-treated PC12 cells.BMC complementary and alternative medicine · 2017Article
- Antidepressant Flavonoids and Their Relationship with Oxidative Stress.Oxidative medicine and cellular longevity · 2017Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHerbal therapies are potential alternatives and adjuncts for depression treatment. The present study aims to investigate the antidepressant-like effects of hydroalcoholic Hemerocallis citrina extracts and its potential neuropharmacological components.
methodsHydroalcoholic H. citrina extracts were phytochemically analyzed. Behavioral models, including tail suspension tests and open field tests, were performed to evaluate the antidepressant-like effects of the extracts. A possible mechanism was explored by analyzing brain monoamine neurotransmitters. Toxicity and histopathological analyses were performed to determine whether or not the extracts are safe for oral administration.
resultsThe antidepressant-like effects of hydroalcoholic H. citrina extracts were mainly related to flavonoids, especially rutin and hesperidin. The extract prepared using 75% ethanol (i.e., HCE75) exhibited the highest active flavonoid content and activity. Orally administered 400 mg/kg of HCE75 significantly induced an antidepressant-like effect, whereas the combination of equivalent rutin and hesperidin dosages exhibited the same profiles. Isobologram analysis showed sub-additive antidepressant interactions between rutin and hesperidin. HCE75 (400 mg/kg, p.o.) increased the serotonin and dopamine levels in the central nervous system. Mortality and lesions were not observed upon oral administration of up to 5000 mg/kg HCE75.
conclusionsThe antidepressant-like effects of hydroalcoholic H. citrina extracts are mainly related to flavonoids, especially rutin and hesperidin. The serotonergic and dopaminergic systems may have major roles. The active extract is toxicologically safe for oral administration.
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