ArticleMagnetic resonance imaging2015
Morphological features of the neonatal brain following exposure to regional anesthesia during labor and delivery.
Article in Magnetic resonance imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Non-pharmacological strategies to obtain usable magnetic resonance images in non-sedated infants: Systematic review and meta-analysis.International journal of nursing studies · 2020Pooled it
- Utilizing maternal prenatal cognition as a predictor of newborn brain measures of intellectual development.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2024Article
- Maternal sevoflurane exposure increases the epilepsy susceptibility of adolescent offspring by interrupting interneuron development.BMC medicine · 2023Article
- Association of labor neuraxial analgesia with autism spectrum disorders in offspring.Journal of anesthesia · 2023Article
- Association of epidural analgesia during labor with neurodevelopment of children during the first three years: the Japan Environment and Children's Study.Environmental health and preventive medicine · 2022Article
- Infant and Child MRI: A Review of Scanning Procedures.Frontiers in neuroscience · 2021Review
- Individual Variation of Human Cortical Structure Is Established in the First Year of Life.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Prenatal socioeconomic status and social support are associated with neonatal brain morphology, toddler language and psychiatric symptoms.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2020Article
- Prenatal exposures and infant brain: Review of magnetic resonance imaging studies and a population description analysis.Human brain mapping · 2019Review
- The Dual Nature of Early-Life Experience on Somatosensory Processing in the Human Infant Brain.Current biology : CB · 2017Article
- Longitudinal study of cerebral surface morphology in youth with 22q11.2 deletion syndrome, and association with positive symptoms of psychosis.Journal of child psychology and psychiatry, and allied disciplines · 2017Article
- Summary of the Update Session on Clinical Neurotoxicity Studies.Journal of neurosurgical anesthesiology · 2016Review
- Prenatal stress alters amygdala functional connectivity in preterm neonates.NeuroImage. Clinical · 2016Article
Corrections and comments
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Authors and funding
18 authors at 2 institutions in 1 country.
Funding
Abstract
introductionRecent animal and human epidemiological studies suggest that early childhood exposure to anesthesia may have adverse effects on brain development. As more than 50% of pregnant women in the United States and one-third in the United Kingdom receive regional anesthesia during labor and delivery, understanding the effects of perinatal anesthesia on postnatal brain development has important public health relevance.
methodsWe used high-resolution magnetic resonance imaging (MRI) to assess the effects of regional anesthesia during labor and delivery as part of a larger study of perinatal exposures on the morphological features of the neonatal brain. We mapped morphological features of the cortical surface in 37 healthy infants, 24 exposed and 13 unexposed to regional anesthesia at delivery, who were scanned within the first 6 weeks of life.
resultsInfants exposed to maternal anesthesia compared with unexposed infants had greater local volumes in portions of the frontal and occipital lobes bilaterally and right posterior portion of the cingulate gyrus. Longer durations of exposure to anesthesia correlated positively with local volumes in the occipital lobe.
conclusionsAnesthesia exposure during labor and delivery was associated with larger volumes in portions of the frontal and occipital lobes and cingulate gyrus in neonates. Longitudinal MRI studies are needed to determine whether these morphological effects of anesthesia persist and what their consequences on cognition and behavior may be.
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