Evidence map›Paper›PMID 25178730›Full record

ArticleNature reviews. Endocrinology2014

Dyslipidaemia: cardiovascular prevention--end of the road for niacin?

Sony Tuteja, Daniel J Rader

Abstract read
PubMed Publisher
In one paragraph

Article in Nature reviews. Endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Current therapies for lowering lipoprotein (a).Journal of lipid research · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sony TutejaDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, 11-125 Smilow Centre for Translational Research, 3400 Civic Centre Blvd, Philadelphia, PA 19104, USA.
Daniel J RaderDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, 11-125 Smilow Centre for Translational Research, 3400 Civic Centre Blvd, Philadelphia, PA 19104, USA.
Translational Therapeutics (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recently published HPS2–THRIVE study has shown that the addition of extended release niacin to statin therapy in patients with well-controlled levels of LDL cholesterol does not reduce the risk of cardiovascular events and might even increase harm. Consequently, the use of niacin to increase levels of HDL cholesterol is not recommended.

Indexed as

Cardiovascular DiseasesCholesterol, HDLCholesterol, LDLDrug Therapy, CombinationDyslipidemiasHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypolipidemic AgentsNiacinTreatment OutcomeCholesterol, HDLCholesterol, LDLHydroxymethylglutaryl-CoA Reductase InhibitorsHypolipidemic AgentsNiacin

Identifiers

PMID25178730
OpenAlexW2002414018

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.