ArticleScientific reports2014
Resting-sate functional reorganization of the rat limbic system following neuropathic injury.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Chronic neuropathic pain alters reversal learning and prefrontal cortex activation without generalized deficits in reward-related behavior.bioRxiv : the preprint server for biology · 2026Article
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- Default mode network-basal ganglia network connectivity predicts the transition to postherpetic neuralgia.IBRO neuroscience reports · 2025Article
- Oxycodone withdrawal induces HDAC1/HDAC2-dependent transcriptional maladaptations in the reward pathway in a mouse model of peripheral nerve injury.Nature neuroscience · 2023Article
- Spinal cord injury in mice amplifies anxiety: A novel light-heat conflict test exposes increased salience of anxiety over heat.Experimental neurology · 2023Article
- Voluntary running-induced activation of ventral hippocampal GABAergic interneurons contributes to exercise-induced hypoalgesia in neuropathic pain model mice.Scientific reports · 2023Article
- Network targets for therapeutic brain stimulation: towards personalized therapy for pain.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Resting-State Functional Connectivity Analyses: Brain Functional Reorganization in a Rat Model of Postherpetic Neuralgia.Brain sciences · 2022Article
- Hippocampus shape deformation: a potential diagnostic biomarker for chronic back pain in women.Pain · 2021Article
- Metabolic Brain Network Analysis WithFrontiers in neurology · 2021Article
- Ultrafast ultrasound imaging pattern analysis reveals distinctive dynamic brain states and potent sub-network alterations in arthritic animals.Scientific reports · 2020Article
- Article
- Gray Matter Volume Changes in Patients With Acute Eye Pain: A Voxel-Based Morphometry Study.Translational vision science & technology · 2019Article
- Primary Role of the Amygdala in Spontaneous Inflammatory Pain- Associated Activation of Pain Networks - A Chemogenetic Manganese-Enhanced MRI Approach.Frontiers in neural circuits · 2019Article
- Inter-subject FDG PET Brain Networks Exhibit Multi-scale Community Structure with Different Normalization Techniques.Annals of biomedical engineering · 2018Article
- Disrupted Resting State Network of Fibromyalgia in Theta frequency.Scientific reports · 2018Article
- Anterior cingulate cortex connectivity is associated with suppression of behaviour in a rat model of chronic pain.Brain and neuroscience advances · 2018Article
- Herpes zoster chronification to postherpetic neuralgia induces brain activity and grey matter volume change.American journal of translational research · 2018Article
- Osteoarthritis pain: What are we learning from animal models?Best practice & research. Clinical rheumatology · 2017Review
- Alterations in the expression of a neurodevelopmental gene exert long-lasting effects on cognitive-emotional phenotypes and functional brain networks: translational evidence from the stress-resilient Ahi1 knockout mouse.Molecular psychiatry · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
Human brain imaging studies from various clinical cohorts show that chronic pain is associated with large-scale brain functional and morphological reorganization. However, how the rat whole-brain network is topologically reorganized to support persistent pain-like behavior following neuropathic injury remains unknown. Here we compare resting state fMRI functional connectivity-based whole-brain network properties between rats receiving spared nerve injury (SNI) vs. sham injury, at 5 days (n = 11 SNI; n = 12 sham) and 28 days (n = 11 SNI; n = 12 sham) post-injury. Similar to the human, the rat brain topological properties exhibited small world features and did not differ between SNI and sham. Local neural networks in SNI animals showed minimal disruption at day 5, and more extensive reorganization at day 28 post-injury. Twenty-eight days after SNI, functional connection changes were localized mainly to within the limbic system, as well as between the limbic and nociceptive systems. No connectivity changes were observed within the nociceptive network. Furthermore, these changes were lateralized and in proportion to the tactile allodynia exhibited by SNI animals. The findings establish that SNI is primarily associated with altered information transfer of limbic regions and provides a novel translational framework for understanding brain functional reorganization in response to a persistent neuropathic injury.
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