ArticleEnvironmental health : a global access science source2014
Exposure characteristics of familial cases of lung injury associated with the use of humidifier disinfectants.
Article in Environmental health : a global access science source, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Health Effects Associated With Humidifier Disinfectant Use: A Systematic Review for Exploration.Journal of Korean medical science · 2022Pooled it
- Effect of Different Molecular Weights of Polyacrylic Acid on Rat Lung Following Intratracheal Instillation.International journal of molecular sciences · 2022Article
- Inflammogenic effect of polyacrylic acid in rat lung following intratracheal instillation.Particle and fibre toxicology · 2022Article
- Need for individual-based evaluation to determine the association between humidifier disinfectants and health injuries.Annals of occupational and environmental medicine · 2021Article
- Comparison of Long Term Follow-up Chest CT Imaging in Adult and Pediatric Patients with Humidifier Disinfectant-related Lung Injury.Journal of Korean medical science · 2020Article
- Potential Health Risks of Chemicals in Car Colorant Products.International journal of environmental research and public health · 2019Article
- Family-based case-control study of exposure to household humidifier disinfectants and risk of idiopathic interstitial pneumonia.PloS one · 2019Article
- Determining Exposure Factors of Anti-Fogging, Dye, Disinfectant, Repellent, and Preservative Products in Korea.International journal of environmental research and public health · 2018Article
- Effects of a mixture of chloromethylisothiazolinone and methylisothiazolinone on peripheral airway dysfunction in children.PloS one · 2017Article
- Humidifier disinfectant-associated lung injury in adults: Prognostic factors in predicting short-term outcome.European radiology · 2017Article
- Article
- Relationship between Exposure to Household Humidifier Disinfectants and Risk of Lung Injury: A Family-Based Study.PloS one · 2015Article
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study describes 17 families with 38 lung injury patients (14 males, 24 females; 22 preschool-age children less than six years of age and 16 individuals of 13-50 years) who used disinfectant added to humidifiers in the home.
methodsClinical examination and humidifier disinfectant-use histories were taken, and a thorough home investigation was performed to assess exposure to humidifier disinfectant.
resultsNine of the patients (three pregnant females, six preschool-age children) died soon after they first developed lung damage. Six (16%) were pregnant females and 22 (58%) were preschool-aged children younger than six years. The patients used humidifier disinfectant products containing either polyhexamethylene guanidine phosphate (PHMG, n = 36) or oligo(2-(2-ethoxy)ethoxyethyl guanidinium chloride (PGH, n = 2). Twenty-six patients (68%) used the brand "Oxy"®, which contains PHMG. Of the ten patients with fatal lung injury, nine were found to have used PHMG.
conclusionsOur findings suggest that the use of humidifier disinfectant products containing either PGH or PHMG can cause lung injury, especially in preschool-age children younger than six years and pregnant women.
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Registered trials
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