ArticleTheScientificWorldJournal2014
Essential oil content of the rhizome of Curcuma purpurascens Bl. (Temu Tis) and its antiproliferative effect on selected human carcinoma cell lines.
Article in TheScientificWorldJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Comparative metabolomic profiling and bioactivities of essential oils from different organs and geographic origins ofFood chemistry: X · 2026Article
- Revolutionizing Curcumin Extraction: New Insights From Non-Conventional Methods-A Comparative Analysis of the Last Decade.Journal of separation science · 2025Review
- Integrative geno-metabolomics of tenasserim turmeric (Computational and structural biotechnology journal · 2025Article
- Evaluation of Bioactive Compounds and Antioxidant and Cytotoxic Effects of Oil and Pulp without Açaí Fat (Foods (Basel, Switzerland) · 2024Article
- Natural essential oils as a new therapeutic tool in colorectal cancer.Cancer cell international · 2022Review
- Chemical Composition and Biological Activities of the Leaf Essential Oils ofAntibiotics (Basel, Switzerland) · 2022Article
- Variable Secondary Metabolite Profiles Across Cultivars ofFrontiers in pharmacology · 2021Article
- Review
- Review
- Assessment of the potential health benefits of certain total extracts fromExperimental and therapeutic medicine · 2015Article
- Inhibitory effect of Curcuma purpurascens BI. rhizome on HT-29 colon cancer cells through mitochondrial-dependent apoptosis pathway.BMC complementary and alternative medicine · 2015Article
- Curcuma purpurascens BI. rhizome accelerates rat excisional wound healing: involvement of Hsp70/Bax proteins, antioxidant defense, and angiogenesis activity.Drug design, development and therapy · 2015Article
- The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats.Drug design, development and therapy · 2015Article
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7 authors.
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Abstract
Curcuma purpurascens Bl., belonging to the Zingiberaceae family, is known as temu tis in Yogyakarta, Indonesia. In this study, the hydrodistilled dried ground rhizome oil was investigated for its chemical content and antiproliferative activity against selected human carcinoma cell lines (MCF7, Ca Ski, A549, HT29, and HCT116) and a normal human lung fibroblast cell line (MRC5). Results from GC-MS and GC-FID analysis of the rhizome oil of temu tis showed turmerone as the major component, followed by germacrone, ar-turmerone, germacrene-B, and curlone. The rhizome oil of temu tis exhibited strong cytotoxicity against HT29 cells (IC50 value of 4.9 ± 0.4 μg/mL), weak cytotoxicity against A549, Ca Ski, and HCT116 cells (with IC50 values of 46.3 ± 0.7, 32.5 ± 1.1, and 35.0 ± 0.3 μg/mL, resp.), and no inhibitory effect against MCF7 cells. It exhibited mild cytotoxicity against a noncancerous human lung fibroblast cell line (MRC5), with an IC50 value of 25.2 ± 2.7 μg/mL. This is the first report on the chemical composition of this rhizome's oil and its selective antiproliferative effect on HT29. The obtained data provided a basis for further investigation of the mode of cell death.
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