ArticleFrontiers in cellular and infection microbiology2014
Functional expression of dental plaque microbiota.
Article in Frontiers in cellular and infection microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 102 citations in OpenAlex.
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- Air restriction enhancesMicrobiology spectrum · 2026Article
- Exploring the oral microbiome: from traditional techniques to advanced omics and databases.Antonie van Leeuwenhoek · 2026Review
- AJournal of bacteriology · 2026Review
- DNA and RNA-based amplicon sequencing of paired supragingival and dentin lesion plaque in children with severe early childhood caries.International journal of oral science · 2026Article
- Multicohort external validation ofFrontiers in cellular and infection microbiology · 2026Article
- Article
- Symbiosis Between the Oral Microbiome and the Human Host: Microbial Homeostasis and Stability of the Host.Advances in experimental medicine and biology · 2025Review
- SMU_1361c regulates the oxidative stress response ofApplied and environmental microbiology · 2024Article
- The Evolving Microbiome of Dental Caries.Microorganisms · 2024Review
- Hub genes and pathways related to caries-free dental biofilm: clinical metatranscriptomic study.Clinical oral investigations · 2023Article
- Comprehensive evaluation of methods for differential expression analysis of metatranscriptomics data.Briefings in bioinformatics · 2023Article
- Illuminating the oral microbiome and its host interactions: recent advancements in omics and bioinformatics technologies in the context of oral microbiome research.FEMS microbiology reviews · 2023Review
- Selenomonas sputigena acts as a pathobiont mediating spatial structure and biofilm virulence in early childhood caries.Nature communications · 2023Article
- Copper ions inhibit Streptococcus mutans-Veillonella parvula dual biofilm by activating Streptococcus mutans reactive nitrogen species.BMC oral health · 2023Article
- The Oral Microbiota in Valvular Heart Disease: Current Knowledge and Future Directions.Life (Basel, Switzerland) · 2023Review
- Imaging biofilms using fluorescenceFrontiers in cellular and infection microbiology · 2023Review
- Dental caries and their microbiomes in children: what do we do now?Journal of oral microbiology · 2023Review
- Managing Oral Health in the Context of Antimicrobial Resistance.International journal of environmental research and public health · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Dental caries remains a significant public health problem and is considered pandemic worldwide. The prediction of dental caries based on profiling of microbial species involved in disease and equally important, the identification of species conferring dental health has proven more difficult than anticipated due to high interpersonal and geographical variability of dental plaque microbiota. We have used RNA-Seq to perform global gene expression analysis of dental plaque microbiota derived from 19 twin pairs that were either concordant (caries-active or caries-free) or discordant for dental caries. The transcription profiling allowed us to define a functional core microbiota consisting of nearly 60 species. Similarities in gene expression patterns allowed a preliminary assessment of the relative contribution of human genetics, environmental factors and caries phenotype on the microbiota's transcriptome. Correlation analysis of transcription allowed the identification of numerous functional networks, suggesting that inter-personal environmental variables may co-select for groups of genera and species. Analysis of functional role categories allowed the identification of dominant functions expressed by dental plaque biofilm communities, that highlight the biochemical priorities of dental plaque microbes to metabolize diverse sugars and cope with the acid and oxidative stress resulting from sugar fermentation. The wealth of data generated by deep sequencing of expressed transcripts enables a greatly expanded perspective concerning the functional expression of dental plaque microbiota.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.