Evidence map›Paper›PMID 25177543›Full record

ArticleProteomes2013

Bioinformatic Analysis of Differential Protein Expression in Calu-3 Cells Exposed to Carbon Nanotubes.

Pin Li, Xianyin Lai, Frank A Witzmann, Bonnie L Blazer-Yost

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteomes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Pin LiDepartment of Biology, Indiana University Purdue University, 723 West Michigan Street, Indianapolis, IN 46202, USA; lipin@iupui.edu.
Xianyin LaiDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine, 1345 West 16th Street, Indianapolis, IN 46202, USA.
Frank A WitzmannDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine, 1345 West 16th Street, Indianapolis, IN 46202, USA.
Bonnie L Blazer-YostDepartment of Biology, Indiana University Purdue University, 723 West Michigan Street, Indianapolis, IN 46202, USA; lipin@iupui.edu ; Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 1345 West 16th Street, Indianapolis, IN 46202, USA.
Indiana University – Purdue University Indianapolis · USIndiana University School of Medicine

Funding

Nanoparticle Effects on Epithelial Cell Protein Expression and FunctionR01GM085218 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI WITZMANN, FRANK A · 2008 to 2012
$2.1M
Characterization Methodologies & Proteomics to Assess Carbon Nanotube ExposureRC2ES018810 · NIEHS · INDIANA UNIVERSITY INDIANAPOLIS · PI MITRA, SOMENATH, WITZMANN, FRANK A · 2009 to 2012
$1.5M
NIEHS NIH HHS RC2 ES018810NIGMS NIH HHS R01 GM085218
6 · The paper itself

Abstract

Carbon nanomaterials are widely produced and used in industry, medicine and scientific research. To examine the impact of exposure to nanoparticles on human health, the human airway epithelial cell line, Calu-3, was used to evaluate changes in the cellular proteome that could account for alterations in cellular function of airway epithelia after 24 hexposure to 10 μg/mL and 100 ng/mL of two common carbon nanoparticles, single- and multi-wall carbon nanotubes (SWCNT, MWCNT). After exposure to the nanoparticles, label-free quantitative mass spectrometry (LFQMS) was used to study the differential protein expression. Ingenuity Pathway Analysis (IPA) was used to conduct a bioinformaticanalysis of proteins identified in LFQMS. Interestingly, after exposure to ahigh concentration (10 μg/mL; 0.4 μg/cm

Indexed as

airway epitheliabarrier epithelialabel-free quantitative mass spectrometryprotein interaction networks

Identifiers

PMID25177543
PMCPMC4148817
OpenAlexW2002966276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.