ArticleMedical gas research2014
Extended normobaric hyperoxia therapy yields greater neuroprotection for focal transient ischemia-reperfusion in rats.
Article in Medical gas research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Adjuvant High-Flow Normobaric Oxygen After Mechanical Thrombectomy for Anterior Circulation Stroke: a Randomized Clinical Trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Trial
- Normobaric Hyperoxia Therapy in Treating Stroke.Clinical interventions in aging · 2025Review
- The neuroprotective effects of normobaric oxygen therapy after stroke.CNS neuroscience & therapeutics · 2024Review
- Review
- Normobaric oxygen therapy attenuates hyperglycolysis in ischemic stroke.Neural regeneration research · 2021Article
- [Propofol combined with hypoxia induces cognitive dysfunction in immature ratsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- Methylene blue and normobaric hyperoxia combination therapy in experimental ischemic stroke.Brain and behavior · 2016Article
- Does normobaric hyperoxia increase oxidative stress in acute ischemic stroke? A critical review of the literature.Medical gas research · 2015Article
- Normobaric oxygen treatment in acute ischemic stroke: a clinical perspective.Medical gas researchReview
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNormobaric hyperoxia (NBO) therapy is neuroprotective in acute ischemic stroke. However, how long the NBO should last to obtain optimal outcome is still unclear. Reports show that ischemic penumbra blood supply may remain compromised for a long period after ischemia-reperfusion, which would impair tissue oxygenation in ischemic penumbra. Therefore, we hypothesized that longer-lasting NBO may yield greater neuroprotection.
methodsThe relationship between treatment outcome and NBO duration was examined in this study. Rats were subjected to 90 min middle cerebral artery occlusion followed by reperfusion for 22.5 hours. NBO started at 30 min post ischemia and lasted for 2, 4 or 8 h. Treatment efficacy was evaluated by measuring infarction volume, oxidative stress and apoptosis.
resultsAmong 2 h, 4 h and 8 h NBO, 8 h NBO offered the greatest efficacy in reducing 24-hour infarction volume, attenuating oxidative stress that was indicated by decreased production of 8-hydroxydeoxyguanosine and NADPH oxidase catalytic subunit gp91(phox), and alleviating apoptosis that was associated with reduced production of DNA fragment and caspase-3 activity in cortex penumbra.
conclusionsUnder our experimental conditions, longer duration of NBO treatment produced greater benefits in focal transient cerebral ischemia-reperfusion rats.
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