ArticleFrontiers in genetics2014
Insights into the epigenomic landscape of the human malaria vector Anopheles gambiae.
Article in Frontiers in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Altered histone modifications in Aedes aegypti midguts following Rift Valley fever virus exposure.Scientific reports · 2026Article
- Chromatin landscape, transcriptomic and ChIP-seq profiling of Anopheles stephensi MSQ43 cell line.Scientific data · 2025Article
- Altered histone modifications inbioRxiv : the preprint server for biology · 2025Article
- Zika virus modulates arthropod histone methylation for its survival in mosquito cells.PloS one · 2025Article
- Identification of long noncoding RNAs (lncRNAs) and co-transcriptional analysis of mRNAs and lncRNAs in transcriptomes ofFrontiers in RNA research · 2025Article
- Mosquito salivary apyrase regulates blood meal hemostasis and facilitates malaria parasite transmission.Nature communications · 2024Article
- Peptides with Antimicrobial Activity in the Saliva of the Malaria VectorInternational journal of molecular sciences · 2024Article
- Article
- ChIP-seq profiling of H3K4me3 and H3K27me3 in an invasive insect,Frontiers in genetics · 2023Article
- Single nucleotide polymorphism (SNP) in theWellcome open research · 2022Article
- Review
- Genome-Wide Mapping of Histone H3 Lysine 4 Trimethylation (H3K4me3) and Its Involvement in Fatty Acid Biosynthesis in Sunflower Developing Seeds.Plants (Basel, Switzerland) · 2021Article
- Review
- bsAS, an antisense long non-coding RNA, essential for correct wing development through regulation of blistered/DSRF isoform usage.PLoS genetics · 2020Article
- Conserved Small Nucleotidic Elements at the Origin of Concerted piRNA Biogenesis from Genes and lncRNAs.Cells · 2020Article
- Chromatin Structure and Function in Mosquitoes.Frontiers in genetics · 2020Review
- Chromatin changes in Anopheles gambiae induced by Plasmodium falciparum infection.Epigenetics & chromatin · 2019Article
- Epigenetic regulation of Plasmodium falciparum clonally variant gene expression during development in Anopheles gambiae.Scientific reports · 2017Article
- "Salivary gland cellular architecture in the Asian malaria vector mosquito Anopheles stephensi".Parasites & vectors · 2015Article
- Unusual chromatin state in Rhynchosciara americana (Diptera: Sciaridae).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Article
Corrections and comments
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4 authors.
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Abstract
The epigenome of the human malaria vector Anopheles gambiae was characterized in midgut cells by mapping the distribution and levels of two post-translational histone modifications, H3K27ac and H3K27me3. These histone profiles were then correlated with levels of gene expression obtained by RNA-seq. Analysis of the transcriptome of A. gambiae midguts and salivary glands led to the discovery of 13,898 new transcripts not present in the most recent genome assembly. A subset of these transcripts is differentially expressed between midgut and salivary glands. The enrichment profiles of H3K27ac and H3K27me3 are mutually exclusive and associate with high and low levels of transcription, respectively. This distribution agrees with previous findings in Drosophila showing association of these two histone modifications with either active or inactive transcriptional states, including Polycomb-associated domains in silenced genes. This study provides a mosquito epigenomics platform for future comparative studies in other mosquito species, opening future investigations into the role of epigenetic processes in vector-borne systems of medical and economic importance.
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