ArticleDementia and geriatric cognitive disorders extra2014
Serum metabolomic biomarkers of dementia.
Article in Dementia and geriatric cognitive disorders extra, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metabolomics in the Development and Progression of Dementia: A Systematic Review.Frontiers in neuroscience · 2019Pooled it
- Beneficial and Detrimental Effects of Uric Acid on Alzheimer's Disease.Current neuropharmacology · 2025Review
- Admission Serum Metabolites and Thyroxine Predict Advanced Hepatic Encephalopathy in a Multicenter Inpatient Cirrhosis Cohort.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023Article
- Integrated analysis of plasma and urine reveals unique metabolomic profiles in idiopathic inflammatory myopathies subtypes.Journal of cachexia, sarcopenia and muscle · 2022Article
- Plasma metabolomic profiles of dementia: a prospective study of 110,655 participants in the UK Biobank.BMC medicine · 2022Article
- Metabolomic and inflammatory signatures of symptom dimensions in major depression.Brain, behavior, and immunity · 2022Article
- Comparison of Antihypertensive Drug Classes for Dementia Prevention.Epidemiology (Cambridge, Mass.) · 2020Article
- Frontal Contribution to Hippocampal Hyperactivity During Memory Encoding in Aging.Frontiers in molecular neuroscience · 2019Article
- Diagnostic Value of Salivary Markers in Neuropsychiatric Disorders.Disease markers · 2019Review
- The Differences of Serum Metabolites Between Patients With Early-Stage Alzheimer's Disease and Mild Cognitive Impairment.Frontiers in neurology · 2019Article
- Alzheimer's Biomarkers From Multiple Modalities Selectively Discriminate Clinical Status: Relative Importance of Salivary Metabolomics Panels, Genetic, Lifestyle, Cognitive, Functional Health and Demographic Risk Markers.Frontiers in aging neuroscience · 2018Article
- Critical review of reporting of the data analysis step in metabolomics.Metabolomics : Official journal of the Metabolomic Society · 2017Article
- Serum Compounds of Energy Metabolism Impairment Are Related to Disability, Disease Course and Neuroimaging in Multiple Sclerosis.Molecular neurobiology · 2017Article
- Antioxidant Defence, Oxidative Stress and Oxidative Damage in Saliva, Plasma and Erythrocytes of Dementia Patients. Can Salivary AGE be a Marker of Dementia?International journal of molecular sciences · 2017Article
- Longitudinal Evidence for Dissociation of Anterior and Posterior MTL Resting-State Connectivity in Aging: Links to Perfusion and Memory.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans.BMC genomics · 2016Article
- Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain.Neurobiology of aging · 2015Article
- Organic Anion Transporter 1 Deficiency Accelerates Learning and Memory Impairment in tg2576 Mice by Damaging Dendritic Spine Morphology and Activity.Journal of molecular neuroscience : MN · 2015Article
- Article
- Free Recall Episodic Memory Performance Predicts Dementia Ten Years prior to Clinical Diagnosis: Findings from the Betula Longitudinal Study.Dementia and geriatric cognitive disorders extraArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThis study compared serum metabolites of demented patients (Alzheimer's disease and vascular dementia) and controls, and explored serum metabolite profiles of nondemented individuals 5 years preceding the diagnosis.
methodsCognitively healthy participants were followed up for 5-20 years. Cognitive assessment, serum sampling, and diagnosis were completed every 5 years. Multivariate analyses were conducted on the metabolite profiles generated by gas chromatography/time-of-flight mass spectrometry.
resultsA significant group separation was found between demented patients and controls, and between incident cases and controls. Metabolites that contributed in both analyses were 3,4-dihydroxybutanoic acid, docosapentaenoic acid, and uric acid.
conclusionsSerum metabolite profiles are altered in demented patients, and detectable up to 5 years preceding the diagnosis. Blood sampling can make an important contribution to the early prediction of conversion to dementia.
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