Evidence map›Paper›PMID 25177322›Full record

ReviewFrontiers in immunology2014

NK Cell Subset Redistribution during the Course of Viral Infections.

Enrico Lugli, Emanuela Marcenaro, Domenico Mavilio

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Host-virus interaction and viral evasion.Cell biology international · 2021
    Review
  11. Review
  12. Immune Dysfunctions of CD56Frontiers in immunology · 2021
    Article
  13. Review
  14. NK cells: A double edge sword against SARS-CoV-2.Advances in biological regulation · 2020
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. CD56Scientific reports · 2019
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Enrico LugliUnit of Clinical and Experimental Immunology, Humanitas Clinical and Research Center , Milan , Italy.
Emanuela MarcenaroDipartimento di Medicina Sperimentale, Centro di Eccellenza per le Ricerche Biomediche, Università degli Studi di Genova , Genova , Italy.
Domenico MavilioUnit of Clinical and Experimental Immunology, Humanitas Clinical and Research Center , Milan , Italy ; Dipartimento di Medicina Sperimentale, Centro di Eccellenza per le Ricerche Biomediche, Università degli Studi di Genova , Genova , Italy ; Department of Medical Biotechnologies and Translational Medicine, University of Milan , Milan , Italy.
Humanitas University · ITUniversity of Genoa · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural killer (NK) cells are important effectors of innate immunity that play a critical role in the control of human viral infections. Indeed, given their capability to directly recognize virally infected cells without the need of specific antigen presentation, NK cells are on the first line of defense against these invading pathogens. By establishing cellular networks with a variety of cell types such as dendritic cells, NK cells can also amplify anti-viral adaptive immune responses. In turn, viruses evolved and developed several mechanisms to evade NK cell-mediated immune activity. It has been reported that certain viral diseases, including human immunodeficiency virus-1 as well as human cytomegalovirus infections, are associated with a pathologic redistribution of NK cell subsets in the peripheral blood. In particular, it has been observed the expansion of unconventional CD56(neg) NK cells, whose effector functions are significantly impaired as compared to that of conventional CD56(pos) NK cells. In this review, we address the impact of these two chronic viral infections on the functional and phenotypic perturbations of human NK cell compartment.

Indexed as

immune activationimmune escapeinnate immune responsephysiophysiological interactionviral infection

Identifiers

PMID25177322
PMCPMC4132273
OpenAlexW2078228665

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.