ArticleRadiology and oncology2014
The effect of radiation dose on mouse skeletal muscle remodeling.
Article in Radiology and oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Review
- Radiation induces long-term muscle fibrosis and promotes a fibrotic phenotype in fibro-adipogenic progenitors.Journal of cachexia, sarcopenia and muscle · 2023Article
- Changes in pectoralis major stiffness and thickness following radiotherapy for breast cancer: A 12-month follow-up case series.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2023Article
- Radiation induced changes in profibrotic markers in the submental muscles and their correlation with tongue movement.PloS one · 2023Article
- The Relationships Between Radiation Dosage and Long-term Swallowing Kinematics and Timing in Nasopharyngeal Carcinoma Survivors.Dysphagia · 2022Article
- Acute effects of radiation treatment to submental muscles on burrowing and swallowing behaviors in a rat model.PloS one · 2022Article
- Effect of postoperative radiotherapy for free flap volume changing after tongue reconstruction.Oral radiology · 2021Article
- Cytokine and Growth Factor Response in a Rat Model of Radiation Induced Injury to the Submental Muscles.Dysphagia · 2021Article
- Chemoradiation impairs myofiber hypertrophic growth in a pediatric tumor model.Scientific reports · 2020Article
- Far-infrared radiation stimulates platelet-derived growth factor mediated skeletal muscle cell migration through extracellular matrix-integrin signaling.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2019Article
- The Effect of Estradiol Administration on Muscle Mass Loss and Cachexia Progression in FemaleFrontiers in endocrinology · 2019Article
- Inflammatory signalling regulates eccentric contraction-induced protein synthesis in cachectic skeletal muscle.Journal of cachexia, sarcopenia and muscle · 2018Article
- A novel in vitro model for the assessment of postnatal myonuclear accretion.Skeletal muscle · 2018Article
- In situ macrophage phenotypic transition is affected by altered cellular composition prior to acute sterile muscle injury.The Journal of physiology · 2017Article
- Influence of longitudinal radiation exposure from microcomputed tomography scanning on skeletal muscle function and metabolic activity in female CD-1 mice.Physiological reports · 2017Article
- Effect of irradiation on Akt signaling in atrophying skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Short-term pyrrolidine dithiocarbamate administration attenuates cachexia-induced alterations to muscle and liver in ApcMin/+ mice.Oncotarget · 2016Article
- A murine model of peripheral irradiation-induced fatigue.Behavioural brain research · 2016Article
- Review
- The emerging role of skeletal muscle oxidative metabolism as a biological target and cellular regulator of cancer-induced muscle wasting.Seminars in cell & developmental biology · 2016Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe purpose of this study was to determine the effect of two clinically relevant radiation doses on the susceptibility of mouse skeletal muscle to remodeling. MATERIALS AND
methodsAlterations in muscle morphology and regulatory signaling were examined in tibialis anterior and gastrocnemius muscles after radiation doses that differed in total biological effective dose (BED). Female C57BL/6 (8-wk) mice were randomly assigned to non-irradiated control, four fractionated doses of 4 Gy (4x4 Gy; BED 37 Gy), or a single 16 Gy dose (16 Gy; BED 100 Gy). Mice were sacrificed 2 weeks after the initial radiation exposure.
resultsThe 16 Gy, but not 4x4 Gy, decreased total muscle protein and RNA content. Related to muscle regeneration, both 16 Gy and 4x4 Gy increased the incidence of central nuclei containing myofibers, but only 16 Gy increased the extracellular matrix volume. However, only 4x4 Gy increased muscle 4-hydroxynonenal expression. While both 16 Gy and 4x4 Gy decreased IIB myofiber mean cross-sectional area (CSA), only 16 Gy decreased IIA myofiber CSA. 16 Gy increased the incidence of small diameter IIA and IIB myofibers, while 4x4 Gy only increased the incidence of small diameter IIB myofibers. Both treatments decreased the frequency and CSA of low succinate dehydrogenase activity (SDH) fibers. Only 16 Gy increased the incidence of small diameter myofibers having high SDH activity. Neither treatment altered muscle signaling related to protein turnover or oxidative metabolism.
conclusionsCollectively, these results demonstrate that radiation dose differentially affects muscle remodeling, and these effects appear to be related to fiber type and oxidative metabolism.
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