Evidence map›Paper›PMID 25177236›Full record

ArticleRadiology and oncology2014

Incidental uptake of (18)F-fluorocholine (FCH) in the head or in the neck of patients with prostate cancer.

Marina Hodolic, Virginie Huchet, Sona Balogova, Laure Michaud, Khaldoun Kerrou, Valérie Nataf, Marino Cimitan, Jure Fettich, Jean-Noël Talbot

Abstract read
In one paragraph

Article in Radiology and oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Additional value of integratedEuropean journal of nuclear medicine and molecular imaging · 2019
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  7. The EANM practice guidelines for parathyroid imaging.European journal of nuclear medicine and molecular imaging · 2021
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  8. Thyroid : official journal of the American Thyroid Association · 2021
    Article
  9. Article
  10. The role ofEJNMMI research · 2019
    Article
  11. Article
  12. Review
  13. Article
  14. Fortuitous discovery of non-fluorocholine-fixing papillary carcinoma of vesicular variant of the thyroid.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019
    Article
  15. Review
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  18. Article
  19. Benefit ofEuropean radiology · 2018
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marina HodolicDepartment for nuclear medicine, University Medical Centre, Ljubljana, Slovenia.
Virginie HuchetMédecine nucléaire, Hôpital Tenon, AP-HP, Paris, France.
Sona BalogovaMédecine nucléaire, Hôpital Tenon, AP-HP, Paris, France ; Comenius University, Bratislava, Slovakia.
Laure MichaudMédecine nucléaire, Hôpital Tenon, AP-HP, Paris, France ; Université Pierre et Marie Curie, Paris, France.
Khaldoun KerrouMédecine nucléaire, Hôpital Tenon, AP-HP, Paris, France.
Valérie NatafMédecine nucléaire, Hôpital Tenon, AP-HP, Paris, France ; Radiopharmacie, Hôpital Tenon, AP-HP, Paris, France.
Marino CimitanNuclear Medicine Unit, National Cancer Institute CRO IRCCS, Aviano, Italy.
Jure FettichDepartment for nuclear medicine, University Medical Centre, Ljubljana, Slovenia.
Jean-Noël TalbotMédecine nucléaire, Hôpital Tenon, AP-HP, Paris, France ; Université Pierre et Marie Curie, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPositron emission tomography-computed tomography (PET/CT) with (18)F-fluorocholine (FCH) is routinely performed in patients with prostate cancer. In this clinical context, foci of FCH uptake in the head or in the neck were considered as incidentalomas, except for those suggestive of multiple bone metastases.

resultsIn 8 patients the incidental focus corresponded to a benign tumour. The standard of truth was histology in two cases, correlative imaging with MRI in four cases, (99m)Tc-SestaMIBI scintigraphy, ultrasonography and biochemistry in one case and biochemistry including PTH assay in one case. The final diagnosis of benign tumours consisted in 3 pituitary adenomas, 2 meningiomas, 2 hyperfunctioning parathyroid glands and 1 thyroid adenoma. Malignancy was proven histologically in 2 other patients: 1 papillary carcinoma of the thyroid and 1 cerebellar metastasis.

conclusionsTo the best of our knowledge, FCH uptake by pituitary adenomas or hyperfunctioning parathyroid glands has never been described previously. We thus discuss whether there might be a future indication for FCH PET/CT when one such tumour is already known or suspected: to detect a residual or recurrent pituitary adenoma after surgery, to guide surgery or radiotherapy of a meningioma or to localise a hyperfunctioning parathyroid gland. In these potential indications, comparative studies with reference PET tracers or with (99m)Tc-sestaMIBI in case of hyperparathyroidism could be undertaken.

Indexed as

FCH, PET/CThyperparathyroidismincidentalomameningiomapituitary adenomathyroid adenoma

Identifiers

PMID25177236
PMCPMC4110078

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.