Evidence map›Paper›PMID 25177211›Full record

ArticleNeoReviews2014

Hypoxic ischemic brain injury: Potential therapeutic interventions for the future.

Aaron J Muller, Jeremy D Marks

Abstract read
In one paragraph

Article in NeoReviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Aaron J MullerDepartment of Pediatrics, University of Chicago 900 East 57th Street Chicago IL 60637.
Jeremy D MarksDepartment of Neurology, University of Chicago 900 East 57th Street Chicago IL 60637.
University of Chicago · US

Funding

Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Mechanisms of Co-Polymer-Mediated NeuroprotectionR01NS056313 · NINDS · UNIVERSITY OF CHICAGO · PI MARKS, JEREMY D · 2007 to 2011
$1.8M
NCATS NIH HHS UL1 TR000430NINDS NIH HHS R01 NS056313
6 · The paper itself

Abstract

Perinatal hypoxic-ischemic brain injury is a common problem with potentially devastating impact on neurodevelopmental outcomes. While therapeutic hypothermia, the first available treatment for this disease, reduces the risk of death or major neurodevelopmental disability, the risk of major neurologic morbidity following HI remains significant. Basic research has identified cellular mechanisms that mediate neuronal death. This article reviews the cellular processes induced that lead to brain injury following HI, and identify treatments currently under investigation for potential translation to clinical trials.

Indexed as

allopurinolerythropoietinexcitotoxicityF-68lipid peroxidationmelatoninnitric oxideoxidative stresspoloxamer 188topiramatexenon

Identifiers

PMID25177211
PMCPMC4148699
OpenAlexW2164601782

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.