Evidence map›Paper›PMID 25177210›Full record

ArticleBMC clinical pathology2014

Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma.

Anna M Wirsing, Oddveig G Rikardsen, Sonja E Steigen, Lars Uhlin-Hansen, Elin Hadler-Olsen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC clinical pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 4 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 4 syntheses or guidelines pooled it, 115 citations in OpenAlex.

  1. The Prognostic Significance of Tertiary Lymphoid Structures in Head and Neck Cancers: A Systematic Review and Meta-Analysis.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026
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  7. Lymphatic Vessel Density or Area Are Not Reliable Prognostic Factors in Oral Cancer.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anna M WirsingDepartment of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø 9037, Norway.
Oddveig G RikardsenDepartment of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø 9037, Norway ; Department of Otorhinolaryngology, University Hospital of North Norway, Tromsø 9038, Norway.
Sonja E SteigenDepartment of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø 9037, Norway ; Diagnostic Clinic - Clinical Pathology, University Hospital of North Norway, Tromsø 9038, Norway.
Lars Uhlin-HansenDepartment of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø 9037, Norway ; Diagnostic Clinic - Clinical Pathology, University Hospital of North Norway, Tromsø 9038, Norway.
Elin Hadler-OlsenDepartment of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø 9037, Norway.
UiT The Arctic University of Norway · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOral squamous cell carcinomas are often heavily infiltrated by immune cells. The organization of B-cells, follicular dendritic cells, T-cells and high-endothelial venules into structures termed tertiary lymphoid structures have been detected in various types of cancer, where their presence is found to predict favourable outcome. The purpose of the present study was to evaluate the incidence of tertiary lymphoid structures in oral squamous cell carcinomas, and if present, analyse whether they were associated with clinical outcome.

methodsTumour samples from 80 patients with oral squamous cell carcinoma were immunohistochemically stained for B-cells, follicular dendritic cells, T-cells, germinal centre B-cells and high-endothelial venules. Some samples were sectioned at multiple levels to assess whether the presence of tertiary lymphoid structures varied within the tumour.

resultsTumour-associated tertiary lymphoid structures were detected in 21 % of the tumours and were associated with lower disease-specific death. The presence of tertiary lymphoid structures varied within different levels of a tissue block.

conclusionsTertiary lymphoid structure formation was found to be a positive prognostic factor for patients with oral squamous cell carcinoma. Increased knowledge about tertiary lymphoid structure formation in oral squamous cell carcinoma might help to develop and guide immune-modulatory cancer treatments.

Indexed as

B-cellFollicular dendritic cellGerminal centreHigh-endothelial venuleOral squamous cell carcinomaPrognostic factorTertiary lymphoid structure

Identifiers

PMID25177210
PMCPMC4148494
OpenAlexW2134307294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.