ArticleThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology2014
Protective effects of the nuclear factor kappa B inhibitor pyrrolidine dithiocarbamate on experimental testicular torsion and detorsion injury.
Article in The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 18 citations in OpenAlex.
- Ultrastructural and histological study of testicular torsion-detorsion on rat and protective effects of fibroblast and macrophage conditioned medium.Veterinary research forum : an international quarterly journal · 2026Article
- Molecular Mechanisms of Testis Damage and Target Drug Development in the Ischemic-Reperfusion Injury of Acute Testicular Torsion: A Pediatric Urological Perspective.The world journal of men's health · 2025Article
- Ovothiol-A Exhibited Protective and Therapeutic Effect against Hyperthyroidism in Rats.Current topics in medicinal chemistry · 2025Article
- Investigation of the role of rosmarinic acid treatment in regulating inflammation, cell damage, and angiogenesis in rat ovarian torsion and detorsion models.Acta cirurgica brasileira · 2020Article
- Comparison of Intraperitoneal and Intratesticular GYY4137 Therapy for the Treatment of Testicular Ischemia Reperfusion Injury in Rats.Current medical science · 2020Article
- Remote ischemic conditioning protects against testicular ischemia∕reperfusion injury in rats.Acta cirurgica brasileira · 2020Article
- miR-33 and RIP140 participate in LPS-induced acute lung injuryTurkish journal of medical sciences · 2019Article
- Effects of sepsis on the metabolism of sphingomyelin and cholesterol in mice with liver dysfunction.Experimental and therapeutic medicine · 2017Article
- Effects of Nitrate Intake on Myocardial Ischemia-Reperfusion Injury in Diabetic Rats.Arquivos brasileiros de cardiologia · 2016Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Testicular torsion results with the damage of the testis and it is a surgical emergency. Pyrrolidine dithiocarbamate (PDTC) is a low-molecular-weight antioxidant and potent inhibitor of nuclear factor kappa B (NF-κB) activation. In this study, we aimed to investigate the effects of PDTC to testicular torsion-detorsion (T/D) injury. Forty adult male Sprague-Dawley rats were separated into four groups. A sham operation was performed in group I. In group II, torsion is performed 2 hours by 720 degree extravaginally testis. In group III, 4 h reperfusion of the testis was performed after 2 h of testicular torsion. In group IV, after performing the same surgical procedures as in group III, PDTC (100 mg/kg, intravenous's) was administered before 30 min of detorsion. The testes tissue malondialdehyde (MDA), superoxide dismutase (SOD) catalase (CAT) level was evaluated. Histological evaluations were performed after hematoxylin and eosin staining. Testicular tissue MDA levels were the highest in the T/D groups compared with treatment group. Administration of PDTC prevented a further increase in MDA levels. Significant decrease occurred in CAT and SOD levels in treatment group compared with the control group. The rats in the treatment group had normal testicular architecture. The results suggest that PDTC can be a potential protective agent for preventing the biochemical and histological changes related to oxidative stress in testicular injury caused by testis torsion.
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