Evidence map›Paper›PMID 25176983›Full record

ReviewHaematologica2014

Early lymphoid lesions: conceptual, diagnostic and clinical challenges.

Karthik A Ganapathi, Stefania Pittaluga, Oreofe O Odejide, Arnold S Freedman, Elaine S Jaffe

Open access · goldAbstract readReview
In one paragraph

Review in Haematologica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 55 citations in OpenAlex.

  1. Precursory or early lesions of follicular lymphoma: clinical features, pathology, and genetics.Journal of clinical and experimental hematopathology : JCEH · 2023
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Smoldering mantle cell lymphoma.Journal of experimental & clinical cancer research : CR · 2017
    Review
  9. Article
  10. Review
  11. Understanding the New WHO Classification of Lymphoid Malignancies: Why It's Important and How It Will Affect Practice.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2017
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. The heterogeneity of follicular lymphomas: from early development to transformation.Virchows Archiv : an international journal of pathology · 2016
    Review
  17. Article
  18. SARS-CoV-2-related immune dysregulation and biologically plausible pathways to lymphomagenesis: a PRISMA-ScR-based scoping review.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Karthik A GanapathiHematopathology Section, Center for Cancer Research, Laboratory of Pathology, National Cancer Institute, Harvard Medical School, Boston, USA.
Stefania PittalugaHematopathology Section, Center for Cancer Research, Laboratory of Pathology, National Cancer Institute, Harvard Medical School, Boston, USA.
Oreofe O OdejideCenter for Hematologic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA.
Arnold S FreedmanCenter for Hematologic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA.
Elaine S JaffeHematopathology Section, Center for Cancer Research, Laboratory of Pathology, National Cancer Institute, Harvard Medical School, Boston, USA ejaffe@mail.nih.gov.
Harvard University · USCenter for Cancer Research · USDana-Farber Cancer Institute · USNational Cancer Institute · US

Funding

Intramural NIH HHS
6 · The paper itself

Abstract

There are no "benign lymphomas", a fact due to the nature of lymphoid cells to circulate and home as part of their normal function. Thus, benign clonal expansions of lymphocytes are only rarely recognized when localized. Recent studies have identified a number of lymphoid proliferations that lie at the interface between benign and malignant. Some of these are clonal proliferations that carry many of the molecular hallmarks of their malignant counterparts, such as BCL2/IGH and CCND1/IGH translocations associated with the in situ forms of follicular lymphoma and mantle cell lymphoma, respectively. There are other clonal B-cell proliferations with low risk of progression; these include the pediatric variants of follicular lymphoma and marginal zone lymphoma. Historically, early or incipient forms of T/NK-cell neoplasia also have been identified, such as lymphomatoid papulosis and refractory celiac disease. More recently an indolent form of T-cell lymphoproliferative disease affecting the gastrointestinal tract has been described. Usually, CD8(+), the clonal cells are confined to the mucosa. The clinical course is chronic, but non-progressive. NK-cell enteropathy is a clinically similar condition, composed of cytologically atypical NK-cells that may involve the stomach, small bowel or colon. Breast implant-associated anaplastic large cell lymphoma is a cytologically alarming lesion that is self-limited if confined to the seroma cavity. Atypical lymphoid proliferations that lie at the border of benign and malignant can serve as instructive models of lymphomagenesis. It is also critical that they be correctly diagnosed to avoid unnecessary and potentially harmful therapy.

Indexed as

Antigens, CDAntineoplastic AgentsBiomarkersB-LymphocytesCell ProliferationClone CellsEarly DiagnosisGene ExpressionHumansImmunophenotypingLymphomaT-LymphocytesTranslocation, GeneticAntigens, CDAntineoplastic AgentsBiomarkers

Identifiers

PMID25176983
PMCPMC4562530
OpenAlexW2065266090

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.