Evidence map›Paper›PMID 25176970›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2014

Depression and anxiety in patients with COPD.

Abebaw M Yohannes, George S Alexopoulos

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04088942 (A Randomized Open-label, Superiority, Multicenter, Two-arm Intervention Study of the Effect of "High-intensity" vs. 'Low-intensity' Smoking Cessation Intervention in Active Smokers With COPD), which is not on this map. Cited by 228 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
228citing papers in PubMed, 11 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04088942 phase4withdrawnnot on this mapstarted 2023, after this paper: background citation

A Randomized Open-label, Superiority, Multicenter, Two-arm Intervention Study of the Effect of "High-intensity" vs. 'Low-intensity' Smoking Cessation Intervention in Active Smokers With COPD

TypeinterventionalSponsorPradeesh SivapalanRan2023 to 2026Enrolled0ConditionsChronic Obstructive Pulmonary Disease, Smoking Cessation, Lung Diseases, Obstructive, Pulmonary Disease, Chronic ObstructiveArmsHigh-intensity smoking cessation intervention, Low-intensity smoking cessation intervention
3 · Its place in the literature

Who cites it

228 citing papers in PubMed, 11 syntheses or guidelines pooled it, 446 citations in OpenAlex.

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  3. Impact of positive airway pressure for chronic hypercapnic respiratory failure on sleep quality: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025
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  5. The Impact of Dance Interventions on Patients with Noninfectious Pulmonary Diseases: A Systematic Review.International journal of environmental research and public health · 2022
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  7. What conservative interventions can improve the long-term quality of life, depression, and anxiety of individuals with stable COPD? A systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022
    Pooled it
  8. Effect of Singing on Symptoms in Stable COPD: A Systematic Review and Meta-Analysis.International journal of chronic obstructive pulmonary disease · 2022
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168 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Abebaw M YohannesDept of Health Professions, The Research Institute for Health and Social Care, Manchester Metropolitan University, Manchester, UK. Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medical College, White Plains, NY, USA A.yohannes@mmu.ac.uk.
George S AlexopoulosDept of Health Professions, The Research Institute for Health and Social Care, Manchester Metropolitan University, Manchester, UK. Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medical College, White Plains, NY, USA.
Manchester Metropolitan University · GB

Funding

Research Methods CoreP30MH085943 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI ALEXOPOULOS, GEORGE S · 2009 to 2013
$9.2M
Treating Older Patients with Major Depression and Severe COPDR01MH076829 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI ALEXOPOULOS, GEORGE S · 2008 to 2012
$1.9M
NIMH NIH HHS P30 MH085943NIMH NIH HHS R01 MH076829
6 · The paper itself

Abstract

Under-recognised and untreated depression and anxiety symptoms have deleterious effects on physical functioning and social interaction increasing fatigue and healthcare utilisation in patients with chronic obstructive pulmonary disease (COPD). Depression and anxiety are challenging to identify and treat because their symptoms often overlap with those of COPD. The cause(s) of depression and anxiety symptoms are multifactorial and include behavioural, social and biological factors. Less than one-third of COPD patients with comorbid depression or anxiety symptoms are receiving appropriate treatment. Factors that contribute to the lack of provision of treatment are varied, they include patient perceived barriers, for example lack of knowledge and reluctance to receive antidepressant drug therapy; poor treatment compliance and lack of a standardised diagnostic approach; and scarcity of adequate resources for mental health treatment. The evidence for the efficacy of antidepressant drug therapy in patients with COPD with comorbid depression and anxiety is inconclusive. There are some promising findings regarding pulmonary rehabilitation, psychological therapy and the collaborative care model in reducing depression and anxiety symptoms in patients with COPD, but these findings are limited by short-term follow-up periods. Further work is required to examine the efficacy of these interventions in randomised controlled trials with larger samples and long-term follow-up.

Indexed as

AnxietyDepressionHumansPulmonary Disease, Chronic Obstructive

Identifiers

PMID25176970
PMCPMC4523084
OpenAlexW2122570705

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.