Evidence map›Paper›PMID 25176968›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2014

Current concepts: host-pathogen interactions in cystic fibrosis airways disease.

Anthony C Tang, Stuart E Turvey, Marco P Alves, Nicolas Regamey, Burkhard Tümmler, Dominik Hartl

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Cystic Fibrosis Clinical Isolates ofPathogens (Basel, Switzerland) · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. A review of inflammatory mechanism in airway diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anthony C TangDept of Pediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada. Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. Division of Pediatric Respiratory Medicine, University Hospital, Bern, Switzerland. Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hanover Medical School, Hanover, Germany. Cystic Fibrosis Research Group, Dept of Pediatrics I, University of Tübingen, Tübingen, Germany. Both authors contributed equally. Dept of Pediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada. Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. Division of Pediatric Respiratory Medicine, University Hospital, Bern, Switzerland. Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hanover Medical School, Hanover, Germany. Cystic Fibrosis Research Group, Dept of Pediatrics I, University of Tübingen, Tübingen, Germany. Both authors contributed equally. Dept of Pediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada. Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. Division of Pediatric Respiratory Medicine, University Hospital, Bern, Switzerland. Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hanover Medical School, Hanover, Germany. Cystic Fibrosis Research Group, Dept of Pediatrics I, University of Tübingen, Tübingen, Germany. Both authors contributed equally.
Stuart E TurveyDept of Pediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada. Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. Division of Pediatric Respiratory Medicine, University Hospital, Bern, Switzerland. Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hanover Medical School, Hanover, Germany. Cystic Fibrosis Research Group, Dept of Pediatrics I, University of Tübingen, Tübingen, Germany. Both authors contributed equally. Dept of Pediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada. Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. Division of Pediatric Respiratory Medicine, University Hospital, Bern, Switzerland. Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hanover Medical School, Hanover, Germany. Cystic Fibrosis Research Group, Dept of Pediatrics I, University of Tübingen, Tübingen, Germany. Both authors contributed equally. Dept of Pediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada. Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. Division of Pediatric Respiratory Medicine, University Hospital, Bern, Switzerland. Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hanover Medical School, Hanover, Germany. Cystic Fibrosis Research Group, Dept of Pediatrics I, University of Tübingen, Tübingen, Germany. Both authors contributed equally.
Marco P AlvesDept of Pediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada. Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. Division of Pediatric Respiratory Medicine, University Hospital, Bern, Switzerland. Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hanover Medical School, Hanover, Germany. Cystic Fibrosis Research Group, Dept of Pediatrics I, University of Tübingen, Tübingen, Germany. Both authors contributed equally.
Nicolas RegameyDept of Pediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada. Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. Division of Pediatric Respiratory Medicine, University Hospital, Bern, Switzerland. Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hanover Medical School, Hanover, Germany. Cystic Fibrosis Research Group, Dept of Pediatrics I, University of Tübingen, Tübingen, Germany. Both authors contributed equally.
Burkhard TümmlerDept of Pediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada. Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. Division of Pediatric Respiratory Medicine, University Hospital, Bern, Switzerland. Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hanover Medical School, Hanover, Germany. Cystic Fibrosis Research Group, Dept of Pediatrics I, University of Tübingen, Tübingen, Germany. Both authors contributed equally.
Dominik HartlDept of Pediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada. Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. Division of Pediatric Respiratory Medicine, University Hospital, Bern, Switzerland. Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hanover Medical School, Hanover, Germany. Cystic Fibrosis Research Group, Dept of Pediatrics I, University of Tübingen, Tübingen, Germany. Both authors contributed equally. Dominik.Hartl@med.uni-tuebingen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic infection and inflammation are defining characteristics of cystic fibrosis (CF) airway disease. Conditions within the airways of patients living with CF are conducive to colonisation by a variety of opportunistic bacterial, viral and fungal pathogens. Improved molecular identification of microorganisms has begun to emphasise the polymicrobial nature of infections in the CF airway microenvironment. Changes to CF airway physiology through loss of cystic fibrosis transmembrane conductance regulator functionality result in a wide range of immune dysfunctions, which permit pathogen colonisation and persistence. This review will summarise the current understanding of how CF pathogens infect, interact with and evade the CF host.

Indexed as

Bacterial InfectionsCystic FibrosisHumansLungLung Diseases, FungalRespiratory Tract DiseasesVirus Diseases

Identifiers

PMID25176968
PMCPMC9487317

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.