Evidence map›Paper›PMID 25176333›Full record

ReviewNature reviews. Cancer2014

Stem cell-based therapies for cancer treatment: separating hope from hype.

Daniel W Stuckey, Khalid Shah

Abstract readReview
In one paragraph

Review in Nature reviews. Cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Cell-drug conjugates.Nature biomedical engineering · 2024
    Review
  12. Article
  13. Auto-loaded TRAIL-exosomes derived from induced neural stem cells for brain cancer therapy.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Article
  14. Review
  15. Cell and gene therapy in neuro-oncology.Handbook of clinical neurology · 2024
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Daniel W StuckeyMolecular Neurotherapy and Imaging Laboratory and the Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
Khalid ShahMolecular Neurotherapy and Imaging Laboratory and the Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA; and the Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts 02138, USA.

Funding

In vivo imaging of encapsulated stem cells in mouse models of tumor resectionR01CA173077 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI SHAH, KHALID A · 2013 to 2017
$1.7M
Developing diagnostic and therapeutic stem cells for cancer therapyR01CA138922 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI SHAH, KHALID A · 2010 to 2014
$1.7M
NCI NIH HHS R01 CA138922NCI NIH HHS R01CA138922NCI NIH HHS R01 CA173077NCI NIH HHS R01CA173077
6 · The paper itself

Abstract

Stem cell-based therapies are emerging as a promising strategy to tackle cancer. Multiple stem cell types have been shown to exhibit inherent tropism towards tumours. Moreover, when engineered to express therapeutic agents, these pathotropic delivery vehicles can effectively target sites of malignancy. This perspective considers the current status of stem cell-based treatments for cancer and provides a rationale for translating the most promising preclinical studies into the clinic.

Indexed as

Stem Cell TransplantationAnimalsAntineoplastic AgentsCombined Modality TherapyDrug CarriersHumansNeoplasmsOncolytic VirotherapyStem CellsAntineoplastic AgentsDrug Carriers

Identifiers

PMID25176333
PMCPMC4234304

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.